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• W2317024591 abstract "Event Abstract Back to Event The origin and migration of cortical neurons in human and mouse Laura A. Elias1*, David V. Hansen1, Arnold R. Kriegstein1 and Jan H. Lui1 1 University of California, Department of Signal Processing, United States The adult cerebral cortex is composed of excitatory and inhibitory neurons that arise from progenitor cells in disparate proliferative regions in the developing brain and follow different migratory paths. Excitatory pyramidal neurons originate near the ventricle and migrate radially to their positions in the cortical plate. Inhibitory interneurons arise in the ventral telencephalon and migrate tangentially to enter the developing cortex before migrating radially to reach their correct laminar position. Radial glia produce both excitatory and inhibitory neurons indirectly, by generating intermediate progenitor cells that undergo symmetric cell divisions to increase the numbers of nerve cells they produce. In the rodent, intermediate progenitor cells generally reside in a subventricular zone (SVZ). We found that in the embryonic human cortex, very large numbers of neuronal stem and intermediate progenitor cells are produced in a proliferative zone not present in the rodent brain, the outer subventricular zone. The medial ganglionic eminence in the fetal human brain also contains a large SVZ and is the source of large numbers of inhibitory cortical neurons. The oSVZ may account for the very large neocortex size peculiar to humans. Gap junction adhesion has recently been shown to play an important mechanistic role in the radial migration of excitatory neurons. Gap junctions are expressed in stem and progenitor cells of the ventral telencephalon as well as migrating neurons. By allowing communication among progenitors or between progenitors and neuroblasts, gap junctions are thought to play a role in regulating cortical development. We asked whether a gap junction-mediated mechanism governs the tangential or radial migration of inhibitory interneurons. Using shRNA knockdown of Cx43 and Cx26 together with rescue experiments, we found that gap junctions are dispensible for the tangential migration of interneurons, but that Cx43 plays a role in the switch from tangential to radial migration that allows interneurons to enter the cortical plate and find their correct laminar position. Moreover, this action is dependent on the adhesive properties and the C-terminus of Cx43, but not the Cx43 channel. Thus, the radial phase of interneuron migration resembles that of excitatory neuron migration in terms of dependence on Cx43 adhesion. These findings also provide mechanistic support for an interaction between migrating interneurons and radial glia during the switch from tangential to radial migration. References 1. Hansen DV, Lui JH, Parker PR, Kriegstein AR. (2010) Neurogenic radial glia in the outer subventricular zone of human neocortex. Nature 464(7288):554-561.2. Elias LA, Turmaine M, Parnavelas JG, Kriegstein AR. (2010) Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons. J Neurosci. 30(20):7072-7077. Conference: EMBO workshop: Gaba Signalling and Brain Networks , Amsterdam, Netherlands, 30 Jun - 2 Jul, 2010. Presentation Type: Oral Presentation Topic: Talks Citation: Elias LA, Hansen DV, Kriegstein AR and Lui JH (2010). The origin and migration of cortical neurons in human and mouse. Conference Abstract: EMBO workshop: Gaba Signalling and Brain Networks . doi: 10.3389/conf.fnins.2010.15.00029 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 Jun 2010; Published Online: 22 Jun 2010. * Correspondence: Laura A Elias, University of California, Department of Signal Processing, San Francisco, United States, KriegsteinA@stemcell.ucsf.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Laura A Elias David V Hansen Arnold R Kriegstein Jan H Lui Google Laura A Elias David V Hansen Arnold R Kriegstein Jan H Lui Google Scholar Laura A Elias David V Hansen Arnold R Kriegstein Jan H Lui PubMed Laura A Elias David V Hansen Arnold R Kriegstein Jan H Lui Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2317024591 title "The origin and migration of cortical neurons in human and mouse" @default.
• W2317024591 doi "https://doi.org/10.3389/conf.fnins.2010.15.00029" @default.
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