FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317046002> ?p ?o ?g. }

• W2317046002 endingPage "A19" @default.
• W2317046002 startingPage "A19.1" @default.
• W2317046002 abstract "<h3>Background</h3> The authors have previously demonstrated that smoking induces citrullination in the lungs of healthy smokers and they know that anticitrullinated protein antibodies (ACPA) develop in rheumatoid arthritis (RA) patients many years before disease onset. It was hypothesised that shared citrullinated targets are present in the lungs and joints of RA affected individuals and sought to investigate this by full-proteome analysis of synovial and lung biopsies of RA patients. <h3>Material and methods</h3> Proteins were extracted from synovial (n=7, five females and two males, median age 58, 66.7% ACPA positive) and lung (n=6, four females and two males, median age 63, 66.7% ACPA positive) biopsies of RA patients. Synovial biopsies were obtained at the time of open surgery from patients with long-standing RA (mean disease duration 24 years). Large bronchi biopsies were obtained by bronchoscopy from patients with newly diagnosed RA (three smokers and three non-smokers) with symptom duration less than 1 year. The proteins were reduced, alkylated and digested with Lys-C, separated by reverse-phase nanoflow-chromatography and analysed by LTQ-Velos-Orbitrap using multiple fragmentation methods. The data were searched against the human International Protein Index database using the Mascot search engine and all citrullinated peptides were manually verified. The degree of modification was quantified manually. The final results were expressed as ratios of citrullinated versus non-modified peptides. <h3>Results</h3> Over 3300 peptides and 500 proteins were identified in the different samples. The overall protein profiles varied between patients. Five of the identified proteins in the synovium (in total eight sites) and four in the lungs (in total four sites) contained citrullinated residues. Two vimentin derived citrullinated peptides were present in a majority of synovial and lung biopsies with slightly higher citrullinated/unmodified peptides ratios in smokers compared to non-smokers (median ratio of 0.03 in smokers and 0.02 in non-smokers for one of the peptides and a median ratio of 4.5 in the smokers and 0.04 in the non-smokers for the second vimentin peptide). While non-modified and citrullinated fibrinogen α-chain derived peptides were present in various amounts in the synovium, only the unmodified sites could be detected in the lungs of a subset of the patients (three out of six). <h3>Conclusions</h3> The authors demonstrate the presence of shared in vivo citrullinated proteins in the joints and lungs of RA individuals, providing further support for the important pathogenic link between joints and lungs in development of RA." @default.
• W2317046002 created "2016-06-24" @default.
• W2317046002 creator A5000843678 @default.
• W2317046002 creator A5007249070 @default.
• W2317046002 creator A5035616333 @default.
• W2317046002 creator A5037843539 @default.
• W2317046002 creator A5046583167 @default.
• W2317046002 creator A5052621225 @default.
• W2317046002 creator A5066824201 @default.
• W2317046002 creator A5071491614 @default.
• W2317046002 creator A5075957668 @default.
• W2317046002 creator A5078864299 @default.
• W2317046002 creator A5079216840 @default.
• W2317046002 creator A5085662493 @default.
• W2317046002 creator A5088539282 @default.
• W2317046002 creator A5088639385 @default.
• W2317046002 date "2012-02-01" @default.
• W2317046002 modified "2023-10-03" @default.
• W2317046002 title "Identification of shared citrullinated immunological targets in the lungs and joints of patients with rheumatoid arthritis" @default.
• W2317046002 doi "https://doi.org/10.1136/annrheumdis-2011-201231.2" @default.
• W2317046002 hasPublicationYear "2012" @default.
• W2317046002 type Work @default.
• W2317046002 sameAs 2317046002 @default.
• W2317046002 citedByCount "5" @default.
• W2317046002 countsByYear W23170460022013 @default.
• W2317046002 countsByYear W23170460022014 @default.
• W2317046002 countsByYear W23170460022016 @default.
• W2317046002 crossrefType "journal-article" @default.
• W2317046002 hasAuthorship W2317046002A5000843678 @default.
• W2317046002 hasAuthorship W2317046002A5007249070 @default.
• W2317046002 hasAuthorship W2317046002A5035616333 @default.
• W2317046002 hasAuthorship W2317046002A5037843539 @default.
• W2317046002 hasAuthorship W2317046002A5046583167 @default.
• W2317046002 hasAuthorship W2317046002A5052621225 @default.
• W2317046002 hasAuthorship W2317046002A5066824201 @default.
• W2317046002 hasAuthorship W2317046002A5071491614 @default.
• W2317046002 hasAuthorship W2317046002A5075957668 @default.
• W2317046002 hasAuthorship W2317046002A5078864299 @default.
• W2317046002 hasAuthorship W2317046002A5079216840 @default.
• W2317046002 hasAuthorship W2317046002A5085662493 @default.
• W2317046002 hasAuthorship W2317046002A5088539282 @default.
• W2317046002 hasAuthorship W2317046002A5088639385 @default.
• W2317046002 hasBestOaLocation W23170460021 @default.
• W2317046002 hasConcept C126322002 @default.
• W2317046002 hasConcept C142724271 @default.
• W2317046002 hasConcept C159654299 @default.
• W2317046002 hasConcept C163764329 @default.
• W2317046002 hasConcept C185592680 @default.
• W2317046002 hasConcept C203014093 @default.
• W2317046002 hasConcept C204787440 @default.
• W2317046002 hasConcept C2776164576 @default.
• W2317046002 hasConcept C2776232647 @default.
• W2317046002 hasConcept C2777468819 @default.
• W2317046002 hasConcept C2777575956 @default.
• W2317046002 hasConcept C2777714996 @default.
• W2317046002 hasConcept C2779129087 @default.
• W2317046002 hasConcept C48632299 @default.
• W2317046002 hasConcept C515207424 @default.
• W2317046002 hasConcept C55493867 @default.
• W2317046002 hasConcept C71924100 @default.
• W2317046002 hasConcept C72563966 @default.
• W2317046002 hasConcept C90924648 @default.
• W2317046002 hasConceptScore W2317046002C126322002 @default.
• W2317046002 hasConceptScore W2317046002C142724271 @default.
• W2317046002 hasConceptScore W2317046002C159654299 @default.
• W2317046002 hasConceptScore W2317046002C163764329 @default.
• W2317046002 hasConceptScore W2317046002C185592680 @default.
• W2317046002 hasConceptScore W2317046002C203014093 @default.
• W2317046002 hasConceptScore W2317046002C204787440 @default.
• W2317046002 hasConceptScore W2317046002C2776164576 @default.
• W2317046002 hasConceptScore W2317046002C2776232647 @default.
• W2317046002 hasConceptScore W2317046002C2777468819 @default.
• W2317046002 hasConceptScore W2317046002C2777575956 @default.
• W2317046002 hasConceptScore W2317046002C2777714996 @default.
• W2317046002 hasConceptScore W2317046002C2779129087 @default.
• W2317046002 hasConceptScore W2317046002C48632299 @default.
• W2317046002 hasConceptScore W2317046002C515207424 @default.
• W2317046002 hasConceptScore W2317046002C55493867 @default.
• W2317046002 hasConceptScore W2317046002C71924100 @default.
• W2317046002 hasConceptScore W2317046002C72563966 @default.
• W2317046002 hasConceptScore W2317046002C90924648 @default.
• W2317046002 hasIssue "Suppl 1" @default.
• W2317046002 hasLocation W23170460021 @default.
• W2317046002 hasOpenAccess W2317046002 @default.
• W2317046002 hasPrimaryLocation W23170460021 @default.
• W2317046002 hasRelatedWork W1969202046 @default.
• W2317046002 hasRelatedWork W1987688608 @default.
• W2317046002 hasRelatedWork W1991344735 @default.
• W2317046002 hasRelatedWork W2013441512 @default.
• W2317046002 hasRelatedWork W2043104746 @default.
• W2317046002 hasRelatedWork W2136800846 @default.
• W2317046002 hasRelatedWork W2428581596 @default.
• W2317046002 hasRelatedWork W3007208539 @default.
• W2317046002 hasRelatedWork W2186227189 @default.
• W2317046002 hasRelatedWork W2503560313 @default.
• W2317046002 hasVolume "71" @default.
• W2317046002 isParatext "false" @default.
• W2317046002 isRetracted "false" @default.

• next