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- W2317070605 abstract "A 44-year-old man began to manifest scattered scaly erythemas on his extremities at age 41. Next year he developed huge subcutaneous tumors on the right popliteal fossa and left buttock extending to thigh. Because biopsy specimens showed granulomatous lesions admixed with lymphocytes, he was diagnosed as sarcoidosis and whole tumor was removed. Three months later, subcutaneous tumors recurred, erythemas increased in number and size, and multiple cutaneous tumors appeared. He was hospitalized for examination on suspicion of malignant lymphoma. Laboratory examination showed high serum lysozyme and angiotensin-converting enzyme level, negative tuberculin test, and no suggestive findings of visceral involvement. Biopsy specimens from inguinal tumor showed a dense infiltrate of lymphoid and histiocytic cells without atypia and epidermotropism throughout the dermis. Histiocytic multinucleated giant cells were also seen. Electron microscopy revealed hyperconvoluted nucleus of lymphoid cells. Immunohistochemical studies disclosed CD3 and CD4 antigens expression of lymphoid cells. Gene rearrangement analysis revealed rearranged bands of β and γ TCR. These findings indicate a diagnosis of a granulomatous variant of CTCL." @default.
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- W2317070605 date "1997-01-01" @default.
- W2317070605 modified "2023-09-26" @default.
- W2317070605 title "A case of T lymphoma with conspicuous multinucleated giant cells." @default.
- W2317070605 doi "https://doi.org/10.5227/skincancer.12.147" @default.
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