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- W2317074997 abstract "We established a brain tumor xenograft to examine the application of gene therapy utilizing a tumor selectively killing gene together with a nonviral gene delivery carrier to treat brain tumor. To do so, we recombined the therapeutic gene apoptin with the JDK vector and delivered it into human brain tumor cells (U87MG) using PAM-RG4 as the gene delivery carrier. Studies in vitro showed that the PAM-R G4/Apoptin polyplex exhibited particularly high transfection activity of over 40% based on fluorescence-activated cell sorting (FACS) analysis and lower cytotoxicity than other control agents. Also, TUNEL assay and DAPI staining verified that tumor cells had undergone apoptosis, which was induced by the apoptin gene. Caspase-3 activity was about two times higher in the therapeutic group. For in vivo studies, the PAM-R G4/Apoptin polyplex was injected into the tumor, which was induced by injecting U87MG cells into the left flank of nude mice and letting them grow to a certain size. The size of the tumor exponentially grew with time in the control groups whereas the treated group did not exhibit any tumor growth. HE 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B90." @default.
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- W2317074997 date "2011-11-12" @default.
- W2317074997 modified "2023-09-24" @default.
- W2317074997 title "Abstract B90: Nonviral delivery of apoptin for the treatment of brain tumor in a newly established brain tumor xenograft." @default.
- W2317074997 doi "https://doi.org/10.1158/1535-7163.targ-11-b90" @default.
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