FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317084009> ?p ?o ?g. }

• W2317084009 endingPage "172" @default.
• W2317084009 startingPage "153" @default.
• W2317084009 abstract "This paper develops and analyzes an age-structured model of HIV infection with various compartments, including target cells, infected cells, viral loads and immune effector cells, to provide a better understanding of the interaction between HIV and the immune system.We show that the proposed model has one uninfected steady state and several infected steady states.We conduct a local stability analysis of these steady states by using a generalized Jacobian matrix method in conjunction with the Laplace transform.In addition, we consider various techniques and ideas from optimal control theory to derive optimal therapy protocols by using two types of dynamic treatment methods representing reverse transcriptase inhibitors and protease inhibitors.We derive the necessary conditions (an optimality system) for optimal control functions by considering the first variations of the Lagrangian.Further, we obtain optimal therapy protocols by solving a large optimality system of equations through the use of a difference scheme based on the Runge-Kutta method.The results of numerical simulations indicate that the optimal therapy protocols can facilitate long-term control of HIV through a strong immune response after the discontinuation of the therapy." @default.
• W2317084009 created "2016-06-24" @default.
• W2317084009 creator A5019121870 @default.
• W2317084009 creator A5023268642 @default.
• W2317084009 creator A5085382950 @default.
• W2317084009 date "2014-01-01" @default.
• W2317084009 modified "2023-10-05" @default.
• W2317084009 title "An age-structured model with immune response of HIV infection: Modeling and optimal control approach" @default.
• W2317084009 cites W1969133711 @default.
• W2317084009 cites W1975778504 @default.
• W2317084009 cites W1987260315 @default.
• W2317084009 cites W1990768351 @default.
• W2317084009 cites W1993918978 @default.
• W2317084009 cites W2030142085 @default.
• W2317084009 cites W2033593383 @default.
• W2317084009 cites W2035537063 @default.
• W2317084009 cites W2044403736 @default.
• W2317084009 cites W2050353131 @default.
• W2317084009 cites W2056370253 @default.
• W2317084009 cites W2061657962 @default.
• W2317084009 cites W2065757233 @default.
• W2317084009 cites W2085722235 @default.
• W2317084009 cites W2090119445 @default.
• W2317084009 cites W2118732329 @default.
• W2317084009 cites W2120179943 @default.
• W2317084009 cites W2128636484 @default.
• W2317084009 cites W2129694350 @default.
• W2317084009 cites W2159090923 @default.
• W2317084009 cites W2169169493 @default.
• W2317084009 cites W2320114104 @default.
• W2317084009 cites W2320747065 @default.
• W2317084009 cites W2333635821 @default.
• W2317084009 cites W4230374657 @default.
• W2317084009 cites W4232201800 @default.
• W2317084009 doi "https://doi.org/10.3934/dcdsb.2014.19.153" @default.
• W2317084009 hasPublicationYear "2014" @default.
• W2317084009 type Work @default.
• W2317084009 sameAs 2317084009 @default.
• W2317084009 citedByCount "11" @default.
• W2317084009 countsByYear W23170840092016 @default.
• W2317084009 countsByYear W23170840092017 @default.
• W2317084009 countsByYear W23170840092019 @default.
• W2317084009 countsByYear W23170840092020 @default.
• W2317084009 countsByYear W23170840092021 @default.
• W2317084009 countsByYear W23170840092022 @default.
• W2317084009 crossrefType "journal-article" @default.
• W2317084009 hasAuthorship W2317084009A5019121870 @default.
• W2317084009 hasAuthorship W2317084009A5023268642 @default.
• W2317084009 hasAuthorship W2317084009A5085382950 @default.
• W2317084009 hasBestOaLocation W23170840091 @default.
• W2317084009 hasConcept C112972136 @default.
• W2317084009 hasConcept C119857082 @default.
• W2317084009 hasConcept C126255220 @default.
• W2317084009 hasConcept C134306372 @default.
• W2317084009 hasConcept C154945302 @default.
• W2317084009 hasConcept C200331156 @default.
• W2317084009 hasConcept C203014093 @default.
• W2317084009 hasConcept C2775924081 @default.
• W2317084009 hasConcept C28826006 @default.
• W2317084009 hasConcept C3013748606 @default.
• W2317084009 hasConcept C33923547 @default.
• W2317084009 hasConcept C41008148 @default.
• W2317084009 hasConcept C47446073 @default.
• W2317084009 hasConcept C86803240 @default.
• W2317084009 hasConcept C8891405 @default.
• W2317084009 hasConcept C91575142 @default.
• W2317084009 hasConcept C97937538 @default.
• W2317084009 hasConceptScore W2317084009C112972136 @default.
• W2317084009 hasConceptScore W2317084009C119857082 @default.
• W2317084009 hasConceptScore W2317084009C126255220 @default.
• W2317084009 hasConceptScore W2317084009C134306372 @default.
• W2317084009 hasConceptScore W2317084009C154945302 @default.
• W2317084009 hasConceptScore W2317084009C200331156 @default.
• W2317084009 hasConceptScore W2317084009C203014093 @default.
• W2317084009 hasConceptScore W2317084009C2775924081 @default.
• W2317084009 hasConceptScore W2317084009C28826006 @default.
• W2317084009 hasConceptScore W2317084009C3013748606 @default.
• W2317084009 hasConceptScore W2317084009C33923547 @default.
• W2317084009 hasConceptScore W2317084009C41008148 @default.
• W2317084009 hasConceptScore W2317084009C47446073 @default.
• W2317084009 hasConceptScore W2317084009C86803240 @default.
• W2317084009 hasConceptScore W2317084009C8891405 @default.
• W2317084009 hasConceptScore W2317084009C91575142 @default.
• W2317084009 hasConceptScore W2317084009C97937538 @default.
• W2317084009 hasIssue "1" @default.
• W2317084009 hasLocation W23170840091 @default.
• W2317084009 hasOpenAccess W2317084009 @default.
• W2317084009 hasPrimaryLocation W23170840091 @default.
• W2317084009 hasRelatedWork W1536863014 @default.
• W2317084009 hasRelatedWork W1586892663 @default.
• W2317084009 hasRelatedWork W2011742510 @default.
• W2317084009 hasRelatedWork W2073802676 @default.
• W2317084009 hasRelatedWork W2783513734 @default.
• W2317084009 hasRelatedWork W2962768803 @default.
• W2317084009 hasRelatedWork W2996333598 @default.
• W2317084009 hasRelatedWork W3003975134 @default.
• W2317084009 hasRelatedWork W3196741607 @default.
• W2317084009 hasRelatedWork W3205649164 @default.

• next