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- W2317095979 abstract "Many pharmacological agents include “inactive” constituents that are used to alter the solubility, stability, or pharmaceutical properties of a drug. These “salts” are often ignored, and the “active ingredient” gets all of the attention. Pamoic acid (4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid) has been used in formulations of several drugs as pamoate salts. This <i>Perspective</i> highlights an <i>Accelerated Communication</i> in this issue (p. 560) that identifies pamoic acid as a potent activator of the orphan G protein-coupled receptor GPR35. This effect may contribute to the pharmacological actions of some agents that are prepared as pamoate salts. Thus, pharmacologists, regulators, and clinicians should “mind their salts” in considering differences among supposedly equivalent agents." @default.
- W2317095979 created "2016-06-24" @default.
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- W2317095979 date "2010-07-22" @default.
- W2317095979 modified "2023-09-27" @default.
- W2317095979 title "Mind Your Salts: When the Inactive Constituent Isn't: Fig. 1." @default.
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- W2317095979 doi "https://doi.org/10.1124/mol.110.067645" @default.
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