Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317102313> ?p ?o ?g. }
- W2317102313 endingPage "919" @default.
- W2317102313 startingPage "910" @default.
- W2317102313 abstract "There is compelling evidence that, beyond their traditional role in hemostasis and thrombosis, platelets play a significant role in mediating hematologic mechanisms of tumor metastasis by directly and indirectly interacting with pro-metastatic cancer cells. With this rationale, we hypothesized that platelets can be an effective paradigm to develop nanomedicine platforms that utilize platelet-mimetic interaction mechanisms for targeted diagnosis and therapy of metastatic cancer cells. Here we report on our investigation of the development of nanoconstructs that interact with metastatic cancer cells via platelet-mimetic heteromultivalent ligand-receptor pathways. For our studies, pro-metastatic human breast cancer cell line MDA-MB-231 was studied for its surface expression of platelet-interactive receptors, in comparison to another low-metastatic human breast cancer cell line, MCF-7. Certain platelet-interactive receptors were found to be significantly overexpressed on the MDA-MB-231 cells, and these cells showed significantly enhanced binding interactions with active platelets compared to MCF-7 cells. Based upon these observations, two specific receptor interactions were selected, and corresponding ligands were engineered onto the surface of liposomes as model nanoconstructs, to enable platelet-mimetic binding to the cancer cells. Our model platelet-mimetic liposomal constructs showed enhanced targeting and attachment of MDA-MB-231 cells compared to the MCF-7 cells. These results demonstrate the promise of utilizing platelet-mimetic constructs in modifying nanovehicle constructs for metastasis-targeted drug as well as modifying surfaces for ex-vivo cell enrichment diagnostic technologies." @default.
- W2317102313 created "2016-06-24" @default.
- W2317102313 creator A5013331794 @default.
- W2317102313 creator A5035996022 @default.
- W2317102313 creator A5056866601 @default.
- W2317102313 creator A5062301447 @default.
- W2317102313 creator A5070140867 @default.
- W2317102313 date "2013-02-14" @default.
- W2317102313 modified "2023-09-25" @default.
- W2317102313 title "A Platelet-Mimetic Paradigm for Metastasis-Targeted Nanomedicine Platforms" @default.
- W2317102313 cites W1551557275 @default.
- W2317102313 cites W1963654724 @default.
- W2317102313 cites W1966182589 @default.
- W2317102313 cites W1966556597 @default.
- W2317102313 cites W1967610989 @default.
- W2317102313 cites W1968519475 @default.
- W2317102313 cites W1969024117 @default.
- W2317102313 cites W1974182660 @default.
- W2317102313 cites W1974463348 @default.
- W2317102313 cites W1975075899 @default.
- W2317102313 cites W1979522770 @default.
- W2317102313 cites W1984952437 @default.
- W2317102313 cites W1986206363 @default.
- W2317102313 cites W1986714589 @default.
- W2317102313 cites W1988607076 @default.
- W2317102313 cites W1989439356 @default.
- W2317102313 cites W1992885568 @default.
- W2317102313 cites W1999302945 @default.
- W2317102313 cites W2003291344 @default.
- W2317102313 cites W2003611957 @default.
- W2317102313 cites W2008581828 @default.
- W2317102313 cites W2009983088 @default.
- W2317102313 cites W2014482710 @default.
- W2317102313 cites W2017440947 @default.
- W2317102313 cites W2018295362 @default.
- W2317102313 cites W2026172548 @default.
- W2317102313 cites W2029194247 @default.
- W2317102313 cites W2030850477 @default.
- W2317102313 cites W2032359181 @default.
- W2317102313 cites W2034187117 @default.
- W2317102313 cites W2046325076 @default.
- W2317102313 cites W2051572649 @default.
- W2317102313 cites W2054320707 @default.
- W2317102313 cites W2057343423 @default.
- W2317102313 cites W2062030037 @default.
- W2317102313 cites W2068566873 @default.
- W2317102313 cites W2070642821 @default.
- W2317102313 cites W2079323372 @default.
- W2317102313 cites W2079844004 @default.
- W2317102313 cites W2081490717 @default.
- W2317102313 cites W2085355966 @default.
- W2317102313 cites W2087528996 @default.
- W2317102313 cites W2088001386 @default.
- W2317102313 cites W2088536552 @default.
- W2317102313 cites W2088649184 @default.
- W2317102313 cites W2094964650 @default.
- W2317102313 cites W2106234498 @default.
- W2317102313 cites W2117206813 @default.
- W2317102313 cites W2120621672 @default.
- W2317102313 cites W2124422993 @default.
- W2317102313 cites W2124998760 @default.
- W2317102313 cites W2126859254 @default.
- W2317102313 cites W2127341029 @default.
- W2317102313 cites W2128237030 @default.
- W2317102313 cites W2128652813 @default.
- W2317102313 cites W2135592764 @default.
- W2317102313 cites W2136404658 @default.
- W2317102313 cites W2138665978 @default.
- W2317102313 cites W2143851656 @default.
- W2317102313 cites W2147447988 @default.
- W2317102313 cites W2148528535 @default.
- W2317102313 cites W2149100735 @default.
- W2317102313 cites W2154848828 @default.
- W2317102313 cites W2155066067 @default.
- W2317102313 cites W2155555524 @default.
- W2317102313 cites W2156122549 @default.
- W2317102313 cites W2158134782 @default.
- W2317102313 cites W2160358377 @default.
- W2317102313 cites W2160463162 @default.
- W2317102313 cites W2255395527 @default.
- W2317102313 cites W2325800317 @default.
- W2317102313 cites W4245880357 @default.
- W2317102313 doi "https://doi.org/10.1021/bm301996p" @default.
- W2317102313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3690560" @default.
- W2317102313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23360320" @default.
- W2317102313 hasPublicationYear "2013" @default.
- W2317102313 type Work @default.
- W2317102313 sameAs 2317102313 @default.
- W2317102313 citedByCount "28" @default.
- W2317102313 countsByYear W23171023132013 @default.
- W2317102313 countsByYear W23171023132014 @default.
- W2317102313 countsByYear W23171023132015 @default.
- W2317102313 countsByYear W23171023132016 @default.
- W2317102313 countsByYear W23171023132017 @default.
- W2317102313 countsByYear W23171023132018 @default.
- W2317102313 countsByYear W23171023132019 @default.
- W2317102313 countsByYear W23171023132021 @default.
- W2317102313 countsByYear W23171023132022 @default.