Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317106822> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2317106822 endingPage "616" @default.
- W2317106822 startingPage "604" @default.
- W2317106822 abstract "新規フルオロキノロン系抗菌剤 Q-35 の 14C 標識体(14C-Q-35)をラットに単回および反復経口投与し，組織内分布について検討した．1．14C-Q-3520mg/kg を単回経口投与後の組織中放射能濃度は，ほとんどの組織で投与30分後にピークに達した．ピーク時の各組織中の放射能濃度は，脳，眼球および脂肪を除くすべての組織で血漿中放射能濃度とほぼ同等かそれ以上であり，放射能の組織移行性は速やかかつ良好であった．また，移行した放射能は速やかに組織から消失した．2．経口投与後，高濃度の放射能の移行がみられた組織中の総放射能は，大部分が未変化の Q-35 として存在し，代謝物はほとんどみられなかった．3．14回反復投与期間中の組織内放射能濃度は，ほとんどすべての組織で初回投与時の組織内濃度とほぼ同様であり，反復投与期間中の尿中および糞中放射能排泄率も，ほぼ一定の排泄推移を示した．また，最終回投与後の組織中放射能濃度は，血漿中濃度とほぼ同様に速やかに減少した．反復投与による組織への蓄積性および残留性はみられなかった．" @default.
- W2317106822 created "2016-06-24" @default.
- W2317106822 creator A5006057524 @default.
- W2317106822 creator A5019857610 @default.
- W2317106822 creator A5030474955 @default.
- W2317106822 creator A5035711261 @default.
- W2317106822 creator A5035973241 @default.
- W2317106822 creator A5044623712 @default.
- W2317106822 creator A5051867714 @default.
- W2317106822 creator A5052546870 @default.
- W2317106822 creator A5054571073 @default.
- W2317106822 creator A5056265427 @default.
- W2317106822 creator A5060534128 @default.
- W2317106822 creator A5074115749 @default.
- W2317106822 creator A5075903129 @default.
- W2317106822 creator A5077901635 @default.
- W2317106822 date "1995-01-01" @default.
- W2317106822 modified "2023-09-26" @default.
- W2317106822 title "Disposition of Q-35. (2). Distribution after Single and Repeated Oral Administration of 14C-Q-35 in Rats." @default.
- W2317106822 cites W1972223067 @default.
- W2317106822 doi "https://doi.org/10.2133/dmpk.10.604" @default.
- W2317106822 hasPublicationYear "1995" @default.
- W2317106822 type Work @default.
- W2317106822 sameAs 2317106822 @default.
- W2317106822 citedByCount "0" @default.
- W2317106822 crossrefType "journal-article" @default.
- W2317106822 hasAuthorship W2317106822A5006057524 @default.
- W2317106822 hasAuthorship W2317106822A5019857610 @default.
- W2317106822 hasAuthorship W2317106822A5030474955 @default.
- W2317106822 hasAuthorship W2317106822A5035711261 @default.
- W2317106822 hasAuthorship W2317106822A5035973241 @default.
- W2317106822 hasAuthorship W2317106822A5044623712 @default.
- W2317106822 hasAuthorship W2317106822A5051867714 @default.
- W2317106822 hasAuthorship W2317106822A5052546870 @default.
- W2317106822 hasAuthorship W2317106822A5054571073 @default.
- W2317106822 hasAuthorship W2317106822A5056265427 @default.
- W2317106822 hasAuthorship W2317106822A5060534128 @default.
- W2317106822 hasAuthorship W2317106822A5074115749 @default.
- W2317106822 hasAuthorship W2317106822A5075903129 @default.
- W2317106822 hasAuthorship W2317106822A5077901635 @default.
- W2317106822 hasBestOaLocation W23171068221 @default.
- W2317106822 hasConcept C110121322 @default.
- W2317106822 hasConcept C134306372 @default.
- W2317106822 hasConcept C15744967 @default.
- W2317106822 hasConcept C17744445 @default.
- W2317106822 hasConcept C199539241 @default.
- W2317106822 hasConcept C2777056448 @default.
- W2317106822 hasConcept C2780765947 @default.
- W2317106822 hasConcept C33923547 @default.
- W2317106822 hasConcept C38022665 @default.
- W2317106822 hasConcept C71924100 @default.
- W2317106822 hasConcept C77805123 @default.
- W2317106822 hasConcept C98274493 @default.
- W2317106822 hasConceptScore W2317106822C110121322 @default.
- W2317106822 hasConceptScore W2317106822C134306372 @default.
- W2317106822 hasConceptScore W2317106822C15744967 @default.
- W2317106822 hasConceptScore W2317106822C17744445 @default.
- W2317106822 hasConceptScore W2317106822C199539241 @default.
- W2317106822 hasConceptScore W2317106822C2777056448 @default.
- W2317106822 hasConceptScore W2317106822C2780765947 @default.
- W2317106822 hasConceptScore W2317106822C33923547 @default.
- W2317106822 hasConceptScore W2317106822C38022665 @default.
- W2317106822 hasConceptScore W2317106822C71924100 @default.
- W2317106822 hasConceptScore W2317106822C77805123 @default.
- W2317106822 hasConceptScore W2317106822C98274493 @default.
- W2317106822 hasIssue "5" @default.
- W2317106822 hasLocation W23171068221 @default.
- W2317106822 hasOpenAccess W2317106822 @default.
- W2317106822 hasPrimaryLocation W23171068221 @default.
- W2317106822 hasRelatedWork W1555144605 @default.
- W2317106822 hasRelatedWork W1983206951 @default.
- W2317106822 hasRelatedWork W1988895703 @default.
- W2317106822 hasRelatedWork W2051808886 @default.
- W2317106822 hasRelatedWork W2142238400 @default.
- W2317106822 hasRelatedWork W2163154965 @default.
- W2317106822 hasRelatedWork W2463077557 @default.
- W2317106822 hasRelatedWork W2744667494 @default.
- W2317106822 hasRelatedWork W3120625362 @default.
- W2317106822 hasRelatedWork W4252178069 @default.
- W2317106822 hasVolume "10" @default.
- W2317106822 isParatext "false" @default.
- W2317106822 isRetracted "false" @default.
- W2317106822 magId "2317106822" @default.
- W2317106822 workType "article" @default.