FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317118021> ?p ?o ?g. }

• W2317118021 endingPage "154" @default.
• W2317118021 startingPage "154" @default.
• W2317118021 abstract "Diagnostic guidelines for Tuberculosis (TB) in HIV infected patients previously relied on microscopy where the value of initial antibiotic treatment for exclusion of pulmonary TB (PTB) was limited. New guidelines rely on the Xpert MTB Rif test (Xpert). However, the value of the antibiotic treatment remains unclear particularly in individuals who are smear-negative and Xpert-negative-given Xpert has only moderate sensitivity for smear-negative PTB. We assessed an algorithm involving initial treatment with antibiotics prior empiric TB treatment in HIV patients with presumptive PTB who were both smear and Xpert negative.We performed a prospective study with six month follow-up to establish patient response to a course of broad spectrum antibiotics prior empiric TB treatment between March 2012 and June 2013. We calculated the proportion of patients who responded to the antibiotic treatment and those who did not. We computed the crude and adjusted odds ratios with their 95% confidence intervals, for response to the antibiotic treatment on various patient characteristics. We report treatment outcomes for patients who received broad spectrum antibiotics only or who were initiated empiric TB treatment.Our cohort comprised 162 smear-negative and Xpert-negative patients, of whom 59% (96 of 162) were female, 81% (131 of 162) were on antiretroviral therapy (ART) for a median of 8.7 months. Overall, 88% (141 of 160) responded to the antibiotic treatment, 8% (12 of 160) got empiric TB treatment and 4% (7 out of 160) were treated for other respiratory disease. The odds of improvement on antibiotics were lower in patients with advanced HIV disease than in patients with early HIV disease. Adjusted odds ratios were significant for HIV clinical stage (AOR; 0.038,) and duration on ART (AOR; 1.038,).The majority of HIV patients with presumptive PTB with smear-negative and Xpert negative results improved on the antibiotic treatment and did not require empiric TB treatment. Initial antibiotic treatment appeared more successful in patients with less advanced HIV disease. Findings from our study suggest it is useful to initiate HIV infected patients with presumptive PTB having smear and Xpert negative results on an initial course of antibiotic treatment prior empiric TB treatment." @default.
• W2317118021 created "2016-06-24" @default.
• W2317118021 creator A5004781847 @default.
• W2317118021 creator A5005476615 @default.
• W2317118021 creator A5007224795 @default.
• W2317118021 creator A5035492079 @default.
• W2317118021 creator A5036791787 @default.
• W2317118021 creator A5037787022 @default.
• W2317118021 creator A5074967283 @default.
• W2317118021 creator A5083823135 @default.
• W2317118021 creator A5091320270 @default.
• W2317118021 date "2016-01-01" @default.
• W2317118021 modified "2023-10-02" @default.
• W2317118021 title "Outcomes of a clinical diagnostic algorithm for management of ambulatory smear and Xpert MTB/Rif negative HIV infected patients with presumptive pulmonary TB in Uganda: a prospective study." @default.
• W2317118021 cites W1509930917 @default.
• W2317118021 cites W1606105143 @default.
• W2317118021 cites W1652831512 @default.
• W2317118021 cites W1728638204 @default.
• W2317118021 cites W1967220130 @default.
• W2317118021 cites W2008035378 @default.
• W2317118021 cites W2027141205 @default.
• W2317118021 cites W2063406094 @default.
• W2317118021 cites W2064562177 @default.
• W2317118021 cites W2064618548 @default.
• W2317118021 cites W2068404366 @default.
• W2317118021 cites W2080927440 @default.
• W2317118021 cites W2087337232 @default.
• W2317118021 cites W2088664758 @default.
• W2317118021 cites W2103345425 @default.
• W2317118021 cites W2107158674 @default.
• W2317118021 cites W2107474460 @default.
• W2317118021 cites W2117810067 @default.
• W2317118021 cites W2140353364 @default.
• W2317118021 cites W2163963318 @default.
• W2317118021 doi "https://doi.org/10.11604/pamj.2016.23.154.7995" @default.
• W2317118021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4894731" @default.
• W2317118021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27303572" @default.
• W2317118021 hasPublicationYear "2016" @default.
• W2317118021 type Work @default.
• W2317118021 sameAs 2317118021 @default.
• W2317118021 citedByCount "2" @default.
• W2317118021 countsByYear W23171180212019 @default.
• W2317118021 countsByYear W23171180212020 @default.
• W2317118021 crossrefType "journal-article" @default.
• W2317118021 hasAuthorship W2317118021A5004781847 @default.
• W2317118021 hasAuthorship W2317118021A5005476615 @default.
• W2317118021 hasAuthorship W2317118021A5007224795 @default.
• W2317118021 hasAuthorship W2317118021A5035492079 @default.
• W2317118021 hasAuthorship W2317118021A5036791787 @default.
• W2317118021 hasAuthorship W2317118021A5037787022 @default.
• W2317118021 hasAuthorship W2317118021A5074967283 @default.
• W2317118021 hasAuthorship W2317118021A5083823135 @default.
• W2317118021 hasAuthorship W2317118021A5091320270 @default.
• W2317118021 hasConcept C126322002 @default.
• W2317118021 hasConcept C142724271 @default.
• W2317118021 hasConcept C156957248 @default.
• W2317118021 hasConcept C188816634 @default.
• W2317118021 hasConcept C2776301714 @default.
• W2317118021 hasConcept C2781069245 @default.
• W2317118021 hasConcept C3017810746 @default.
• W2317118021 hasConcept C35785553 @default.
• W2317118021 hasConcept C501593827 @default.
• W2317118021 hasConcept C71924100 @default.
• W2317118021 hasConcept C72563966 @default.
• W2317118021 hasConcept C86803240 @default.
• W2317118021 hasConcept C89423630 @default.
• W2317118021 hasConceptScore W2317118021C126322002 @default.
• W2317118021 hasConceptScore W2317118021C142724271 @default.
• W2317118021 hasConceptScore W2317118021C156957248 @default.
• W2317118021 hasConceptScore W2317118021C188816634 @default.
• W2317118021 hasConceptScore W2317118021C2776301714 @default.
• W2317118021 hasConceptScore W2317118021C2781069245 @default.
• W2317118021 hasConceptScore W2317118021C3017810746 @default.
• W2317118021 hasConceptScore W2317118021C35785553 @default.
• W2317118021 hasConceptScore W2317118021C501593827 @default.
• W2317118021 hasConceptScore W2317118021C71924100 @default.
• W2317118021 hasConceptScore W2317118021C72563966 @default.
• W2317118021 hasConceptScore W2317118021C86803240 @default.
• W2317118021 hasConceptScore W2317118021C89423630 @default.
• W2317118021 hasLocation W23171180211 @default.
• W2317118021 hasLocation W23171180212 @default.
• W2317118021 hasOpenAccess W2317118021 @default.
• W2317118021 hasPrimaryLocation W23171180211 @default.
• W2317118021 hasRelatedWork W2038162802 @default.
• W2317118021 hasRelatedWork W2039467565 @default.
• W2317118021 hasRelatedWork W2318248509 @default.
• W2317118021 hasRelatedWork W2323960513 @default.
• W2317118021 hasRelatedWork W2413067036 @default.
• W2317118021 hasRelatedWork W2766832809 @default.
• W2317118021 hasRelatedWork W2969016624 @default.
• W2317118021 hasRelatedWork W3000734051 @default.
• W2317118021 hasRelatedWork W3034420799 @default.
• W2317118021 hasRelatedWork W4306253738 @default.
• W2317118021 hasVolume "23" @default.
• W2317118021 isParatext "false" @default.
• W2317118021 isRetracted "false" @default.
• W2317118021 magId "2317118021" @default.
• W2317118021 workType "article" @default.