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• W2317147533 abstract "Event Abstract Back to Event Frequency of lymphomas in a cohort of Common Variable Immunodeficiency (CVID) patients Bruno Sini1, 2, Cristina M. Kokron1*, Debora Levy2, Juliana Pereira2, Ana Karolina B. Oliveira1, Andrea Cohon1, Jorge Kalil1, Sergio Bydlowski2 and Myrthes T. Barros1 1 University of São Paulo Medical School, Division of Clinical Immunology and Allergy and Laboratory of Clinical Immunology and Allergy, LIM-60, Brazil 2 University of São Paulo Medical School, Laboratory of Genetics and Molecular Hematology (LIM31), Brazil Our objective was to evaluate the frequency of lymphomas in a cohort of CVID followed at the PID Clinic. Methods: Analysis of data obtained from medical records. Results: We analyzed 144 CVID patients followed between 1985 and 2012, being 80 men, aged 15-72 years at diagnosis. Seven lymphoma cases were diagnosed (0.5% - 5 men, 2 women) being 1 Hodgkin lymphoma, 6 non-Hodgkin lymphomas. Age of onset of CVID symptoms ranged from 2 - 53y, age at CVID diagnosis from 5 - 55y, age of lymphoma diagnosis from 19 - 53y. The time period between CVID onset of symptoms and lymphoma diagnosis ranged from 7 to 24 years in 4 patients and in 3 the diagnosis of CVID and lymphoma nearly overlapped, preceding CVID diagnosis in only 1 to 6 months. Lymphoma´s manifestations like fever of unknown origin, weight loss, splenomegaly and lymphadenopathy occurred in 100% of patients. Other manifestations observed: renal infiltration (2), hepatic infiltration (4), pulmonary infiltrates (3) and mediastinal mass (1). Three deaths due to lymphoma occurred during the study. Two patients presented lymphocytosis with inversion of CD4/CD8 ratio and one lymphopenia. Increased NK cells were observed in 3. Three patients in whom diagnosis of lymphoma and CVID were simultaneous presented undetectable B lymphocytes while in one, B cells were present at CVID diagnosis but undetectable at lymphoma diagnosis. Conclusions: Patients with absence of B cells in recently diagnosed CVID or vanishing B cells in long term follow-up CVID demands a screening for the presence of lymphomas. Keywords: CVID, humoral immunity, Lymphoma, B lymphocytes, Lymphopenia Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Adaptive Immunity Citation: Sini B, Kokron CM, Levy D, Pereira J, Oliveira AB, Cohon A, Kalil J, Bydlowski S and Barros MT (2013). Frequency of lymphomas in a cohort of Common Variable Immunodeficiency (CVID) patients. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00989 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Cristina M Kokron, University of São Paulo Medical School, Division of Clinical Immunology and Allergy and Laboratory of Clinical Immunology and Allergy, LIM-60, São Paulo, Brazil, cmkokron@usp.br Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Bruno Sini Cristina M Kokron Debora Levy Juliana Pereira Ana Karolina B Oliveira Andrea Cohon Jorge Kalil Sergio Bydlowski Myrthes T Barros Google Bruno Sini Cristina M Kokron Debora Levy Juliana Pereira Ana Karolina B Oliveira Andrea Cohon Jorge Kalil Sergio Bydlowski Myrthes T Barros Google Scholar Bruno Sini Cristina M Kokron Debora Levy Juliana Pereira Ana Karolina B Oliveira Andrea Cohon Jorge Kalil Sergio Bydlowski Myrthes T Barros PubMed Bruno Sini Cristina M Kokron Debora Levy Juliana Pereira Ana Karolina B Oliveira Andrea Cohon Jorge Kalil Sergio Bydlowski Myrthes T Barros Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2317147533 title "Frequency of lymphomas in a cohort of Common Variable Immunodeficiency (CVID) patients" @default.
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