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• W2317149712 abstract "Surgical therapy for Crohn's disease (CD) does not result in cure. Clinical and endoscopic recurrence are frequently found in long-term follow up of CD patients. Phenotype and histopathological characteristics, medication on the pre and postoperative scenario and surgical technique details, among other variables, can influence the rates of postoperative endoscopic recurrence after resections. The aim of this study was to analyze the rates of endoscopic recurrence in a cohort of CD patients, and define risk factors for its occurrence. Multicenter, observational and retrospective study, with CD patients, submitted to ileocecal resection and had endoscopic follow-up for recurrence analysis. Analyzed variables: demographic data, Montreal classification, associated procedures, type of operation (conventional or laparoscopic), type of anastomosis (stapled or hand-sewn), residual CD, medication on the pre and postoperative setting, granulomas, and presence of recurrence according to the Rutgeerts' score. Endoscopic recurrence was defined as Rutgeerts' score ≥ i-2. Patients were classified into 2 groups, according to the presence or not of postoperative endoscopic recurrence on the first colonoscopy after the operations. The studied variables were tested to analyze risk factors for recurrence. Statistical analysis: exact Fischer test or Mann-Whitney (qualitative variables), and Student's t test or Mann-Whitney (quantitative variables). Statistical significance was considered with P < 0.05. A total of 85 patients were included, 48 men (56.8%), with median age at diagnosis of 33,1 years (14–63) and CD duration of 84.5 (2–300) months. From these, 28 (32.9%) had endoscopic recurrence, and 57 (67.1%) had not. There was no significant difference between the groups in relation to age (P = 0.753), CD duration (P = 0.193), length of surgical specimen (P = 0.536), granulomas (P = 1.000), CD location (P = 0.792), phenotype of the disease (P = 0.329), smoking (P = 0.565), type of anastomosis (P = 1.000) and perianal disease (P = 1.000). The only risk factor with significant difference between the groups was preoperative use of corticosteroids (50% on patients with recurrence and 26,5% on the patients with endoscopic normality, P = 0.044). Preoperative use of corticosteroids was the only risk factor identified for postoperative endoscopic recurrence in this study. There was no influence of disease characteristics, pathologic features or surgical technique details on the recurrence rates." @default.
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• W2317149712 date "2013-12-01" @default.
• W2317149712 modified "2023-10-16" @default.
• W2317149712 title "P-128 Risk Factors for Postoperative Endoscopic Recurrence in Crohnʼs Disease" @default.
• W2317149712 doi "https://doi.org/10.1097/01.mib.0000438806.12517.23" @default.
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