FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317164051> ?p ?o ?g. }

• W2317164051 endingPage "G356" @default.
• W2317164051 startingPage "G345" @default.
• W2317164051 abstract "The spatial orientation of the enteroendocrine cells along the crypt-villus axis is closely associated with their differentiation in the intestine. Here we studied this relationship using primary duodenal crypts and an ex vivo organoid system established from cholecystokinin-green fluorescent protein (CCK-GFP) transgenic mice. In the primary duodenal crypts, GFP+ cells were found not only in the upper crypt but also at the crypt base, where the stem cells reside. Many GFP+ cells below +4 position were positive for the putative intestinal stem cell markers, leucine-rich repeat-containing G protein-coupled receptor 5, CD133, and doublecortin and CaM kinase-like-1, and also for the neuroendocrine transcription factor neurogenin 3. However, these cells were neither stem nor transient amplifying precursor cells because they were negative for both Ki-67 and phospho-Histone H3 and positive for the mature endocrine marker chromogranin A. Furthermore, these cells expressed multiple endocrine hormones. Tracking of GFP+ cells in the organoids from CCK-GFP mice indicated that GFP+ cells were first observed around the +4 position, some of which localized to the crypt base later in the culture period. These results suggest that a subset of enteroendocrine cells migrates down to the crypt base or stays localized at the crypt base, where they express stem and postmitotic endocrine markers. Further investigation of the function of this subset may provide novel insights into the genesis and development of enteroendocrine cells as well as enteroendocrine tumorigenesis." @default.
• W2317164051 created "2016-06-24" @default.
• W2317164051 creator A5020411590 @default.
• W2317164051 creator A5026111016 @default.
• W2317164051 creator A5073279939 @default.
• W2317164051 creator A5080649327 @default.
• W2317164051 creator A5084210961 @default.
• W2317164051 date "2011-02-01" @default.
• W2317164051 modified "2023-10-13" @default.
• W2317164051 title "A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine" @default.
• W2317164051 cites W1568038787 @default.
• W2317164051 cites W1964423718 @default.
• W2317164051 cites W1965157206 @default.
• W2317164051 cites W1982603620 @default.
• W2317164051 cites W1999172670 @default.
• W2317164051 cites W2005113993 @default.
• W2317164051 cites W2017400430 @default.
• W2317164051 cites W2023351030 @default.
• W2317164051 cites W2025659071 @default.
• W2317164051 cites W2045467715 @default.
• W2317164051 cites W2046349824 @default.
• W2317164051 cites W2046881486 @default.
• W2317164051 cites W2049792810 @default.
• W2317164051 cites W2050610306 @default.
• W2317164051 cites W2056199674 @default.
• W2317164051 cites W2067526109 @default.
• W2317164051 cites W2070193827 @default.
• W2317164051 cites W2072287846 @default.
• W2317164051 cites W2081471404 @default.
• W2317164051 cites W2082867256 @default.
• W2317164051 cites W2084745919 @default.
• W2317164051 cites W2088125351 @default.
• W2317164051 cites W2117374458 @default.
• W2317164051 cites W2123022068 @default.
• W2317164051 cites W2123196611 @default.
• W2317164051 cites W2135340140 @default.
• W2317164051 cites W2137790111 @default.
• W2317164051 cites W2142486892 @default.
• W2317164051 cites W2160400743 @default.
• W2317164051 cites W2169745228 @default.
• W2317164051 cites W2171560127 @default.
• W2317164051 cites W2404992695 @default.
• W2317164051 cites W3154136004 @default.
• W2317164051 doi "https://doi.org/10.1152/ajpgi.00278.2010" @default.
• W2317164051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3043655" @default.
• W2317164051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21088235" @default.
• W2317164051 hasPublicationYear "2011" @default.
• W2317164051 type Work @default.
• W2317164051 sameAs 2317164051 @default.
• W2317164051 citedByCount "55" @default.
• W2317164051 countsByYear W23171640512012 @default.
• W2317164051 countsByYear W23171640512013 @default.
• W2317164051 countsByYear W23171640512014 @default.
• W2317164051 countsByYear W23171640512015 @default.
• W2317164051 countsByYear W23171640512016 @default.
• W2317164051 countsByYear W23171640512017 @default.
• W2317164051 countsByYear W23171640512018 @default.
• W2317164051 countsByYear W23171640512019 @default.
• W2317164051 countsByYear W23171640512020 @default.
• W2317164051 countsByYear W23171640512021 @default.
• W2317164051 countsByYear W23171640512022 @default.
• W2317164051 countsByYear W23171640512023 @default.
• W2317164051 crossrefType "journal-article" @default.
• W2317164051 hasAuthorship W2317164051A5020411590 @default.
• W2317164051 hasAuthorship W2317164051A5026111016 @default.
• W2317164051 hasAuthorship W2317164051A5073279939 @default.
• W2317164051 hasAuthorship W2317164051A5080649327 @default.
• W2317164051 hasAuthorship W2317164051A5084210961 @default.
• W2317164051 hasBestOaLocation W23171640512 @default.
• W2317164051 hasConcept C103395026 @default.
• W2317164051 hasConcept C104317684 @default.
• W2317164051 hasConcept C134018914 @default.
• W2317164051 hasConcept C136302470 @default.
• W2317164051 hasConcept C142613039 @default.
• W2317164051 hasConcept C153911025 @default.
• W2317164051 hasConcept C28328180 @default.
• W2317164051 hasConcept C31695470 @default.
• W2317164051 hasConcept C46699223 @default.
• W2317164051 hasConcept C55493867 @default.
• W2317164051 hasConcept C66090201 @default.
• W2317164051 hasConcept C71315377 @default.
• W2317164051 hasConcept C86803240 @default.
• W2317164051 hasConcept C95444343 @default.
• W2317164051 hasConceptScore W2317164051C103395026 @default.
• W2317164051 hasConceptScore W2317164051C104317684 @default.
• W2317164051 hasConceptScore W2317164051C134018914 @default.
• W2317164051 hasConceptScore W2317164051C136302470 @default.
• W2317164051 hasConceptScore W2317164051C142613039 @default.
• W2317164051 hasConceptScore W2317164051C153911025 @default.
• W2317164051 hasConceptScore W2317164051C28328180 @default.
• W2317164051 hasConceptScore W2317164051C31695470 @default.
• W2317164051 hasConceptScore W2317164051C46699223 @default.
• W2317164051 hasConceptScore W2317164051C55493867 @default.
• W2317164051 hasConceptScore W2317164051C66090201 @default.
• W2317164051 hasConceptScore W2317164051C71315377 @default.
• W2317164051 hasConceptScore W2317164051C86803240 @default.
• W2317164051 hasConceptScore W2317164051C95444343 @default.
• W2317164051 hasIssue "2" @default.

• next