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• W2317165612 abstract "Summary Background: Escherichia coli populations in the gut increase after weaning, releasing cell wall lipopolysaccharides (LPS), which are potent pro-inflammatory substances. Objective: this study evaluated LPS intake effects on protein expression and activity of intestinal disaccharidases and aminopetidases. Methods: sixty-four pigs (weaning age: 21 d) were fed a basal diet with added LPS (0.0, 0.3, 0.5, and 1.0 µg LPS/mg feed) during 10 days post-weaning. Pigs were slaughtered on days 1, 5, 7, and 10 post-weaning to assess small intestine molecular expression and enzyme activity. A randomized block design in a 4x4 factorial arrangement was used. Results: intestinal enzyme expression and activity was lower in pigs fed the highest LPS level (p<0.01). Enzyme values were lowest at day 10 (p<0.01). The highest gene expression and enzyme activity was observed in duodenum (p<0.01). Conclusions: data from this study suggest that LPS from E. coli decreases intestinal enzyme expression and activity." @default.
• W2317165612 created "2016-06-24" @default.
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• W2317165612 date "2015-01-01" @default.
• W2317165612 modified "2023-10-11" @default.
• W2317165612 title "Escherichia coli lipopolysaccharides decrease molecular expression and activity of disaccharidases and aminopeptidases" @default.
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