FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317196060> ?p ?o ?g. }

• W2317196060 abstract "c-myc is the main proto-oncogene responsible for restenosis in cardiovascular surgery. The aim of our study was to evaluate the effects of c-myc antisense (AS) phosphorothioate oligodeoxynucleotides (ODNs) in the remodelling process induced by surgical carotid arteriotomy on an experimental rat model.Fifty-five rats with carotid stenosis and apoptosis induced by arteriotomy were submitted to gene expression analysis 4 h after surgery, to TUNEL assay 48 h after surgery and to histological analysis 30 days later.AS ODNs induced a 60% decrease in target c-myc mRNA in injured carotid arteries compared to control sense and scrambled ODN-treated carotid arteries (P < 0.05). Histological evaluation revealed that stenosis stimulated by arteriotomy was mainly due to adventitial constrictive remodelling rather than to neointimal hyperplasia, observed only in a limited number of samples. Morphometric analysis showed that lumen area in c-myc AS ODN-treated carotid arteries was 35% greater than in control arteries (P < 0.05), whereas the media/lumen area ratio showed a 63% reduction in AS ODN-treated carotid arteries in comparison to control arteries (P < 0.05). Surgical injury affected the expression of apoptosis-related genes Bcl-2, Bax, Bcl-xL and Bcl-xS, inducing a mean 3.5-fold decrease in the Bcl-2/ Bax ratio and a 9-fold decrease in the Bcl-xL/S ratio 4 h after injury as compared with uninjured carotid arteries. TUNEL assay experiments revealed increased apoptosis in AS ODN-treated carotid arteries in comparison to control carotid arteries.c-myc AS ODNs reduce the negative remodelling induced by arteriotomy. The imbalance between proliferative stimulus represented by surgery and the c-myc mRNA decrease induced greater apoptosis in AS ODN-treated carotid arteries without further affecting mRNA levels of Bcl-2, Bax, Bcl-xL and Bcl-xS genes." @default.
• W2317196060 created "2016-06-24" @default.
• W2317196060 creator A5007203413 @default.
• W2317196060 creator A5010570514 @default.
• W2317196060 creator A5014413926 @default.
• W2317196060 creator A5046691342 @default.
• W2317196060 creator A5047113086 @default.
• W2317196060 creator A5055055447 @default.
• W2317196060 creator A5062560623 @default.
• W2317196060 creator A5072788055 @default.
• W2317196060 date "2006-01-01" @default.
• W2317196060 modified "2023-09-22" @default.
• W2317196060 title "Rat carotid arteriotomy: c-myc is involved in negative remodelling and apoptosis" @default.
• W2317196060 cites W1796908871 @default.
• W2317196060 cites W1897252591 @default.
• W2317196060 cites W1963626132 @default.
• W2317196060 cites W1963927454 @default.
• W2317196060 cites W1968692561 @default.
• W2317196060 cites W1977392841 @default.
• W2317196060 cites W1994616247 @default.
• W2317196060 cites W1995996044 @default.
• W2317196060 cites W1999538767 @default.
• W2317196060 cites W1999959802 @default.
• W2317196060 cites W2001858780 @default.
• W2317196060 cites W2003299823 @default.
• W2317196060 cites W2035341384 @default.
• W2317196060 cites W2038870579 @default.
• W2317196060 cites W2043645992 @default.
• W2317196060 cites W2044266962 @default.
• W2317196060 cites W2066387850 @default.
• W2317196060 cites W2073785014 @default.
• W2317196060 cites W2077082072 @default.
• W2317196060 cites W2111638383 @default.
• W2317196060 cites W2128653564 @default.
• W2317196060 cites W2141232186 @default.
• W2317196060 cites W2427502382 @default.
• W2317196060 doi "https://doi.org/10.2459/01.jcm.0000199779.92967.59" @default.
• W2317196060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16645362" @default.
• W2317196060 hasPublicationYear "2006" @default.
• W2317196060 type Work @default.
• W2317196060 sameAs 2317196060 @default.
• W2317196060 citedByCount "4" @default.
• W2317196060 countsByYear W23171960602018 @default.
• W2317196060 crossrefType "journal-article" @default.
• W2317196060 hasAuthorship W2317196060A5007203413 @default.
• W2317196060 hasAuthorship W2317196060A5010570514 @default.
• W2317196060 hasAuthorship W2317196060A5014413926 @default.
• W2317196060 hasAuthorship W2317196060A5046691342 @default.
• W2317196060 hasAuthorship W2317196060A5047113086 @default.
• W2317196060 hasAuthorship W2317196060A5055055447 @default.
• W2317196060 hasAuthorship W2317196060A5062560623 @default.
• W2317196060 hasAuthorship W2317196060A5072788055 @default.
• W2317196060 hasConcept C126322002 @default.
• W2317196060 hasConcept C126894567 @default.
• W2317196060 hasConcept C131631996 @default.
• W2317196060 hasConcept C142724271 @default.
• W2317196060 hasConcept C185592680 @default.
• W2317196060 hasConcept C190283241 @default.
• W2317196060 hasConcept C196795494 @default.
• W2317196060 hasConcept C204232928 @default.
• W2317196060 hasConcept C2776725920 @default.
• W2317196060 hasConcept C2776820930 @default.
• W2317196060 hasConcept C2777339539 @default.
• W2317196060 hasConcept C2778283817 @default.
• W2317196060 hasConcept C2778583881 @default.
• W2317196060 hasConcept C2779305218 @default.
• W2317196060 hasConcept C2779450455 @default.
• W2317196060 hasConcept C2780007028 @default.
• W2317196060 hasConcept C2987047532 @default.
• W2317196060 hasConcept C55493867 @default.
• W2317196060 hasConcept C71924100 @default.
• W2317196060 hasConceptScore W2317196060C126322002 @default.
• W2317196060 hasConceptScore W2317196060C126894567 @default.
• W2317196060 hasConceptScore W2317196060C131631996 @default.
• W2317196060 hasConceptScore W2317196060C142724271 @default.
• W2317196060 hasConceptScore W2317196060C185592680 @default.
• W2317196060 hasConceptScore W2317196060C190283241 @default.
• W2317196060 hasConceptScore W2317196060C196795494 @default.
• W2317196060 hasConceptScore W2317196060C204232928 @default.
• W2317196060 hasConceptScore W2317196060C2776725920 @default.
• W2317196060 hasConceptScore W2317196060C2776820930 @default.
• W2317196060 hasConceptScore W2317196060C2777339539 @default.
• W2317196060 hasConceptScore W2317196060C2778283817 @default.
• W2317196060 hasConceptScore W2317196060C2778583881 @default.
• W2317196060 hasConceptScore W2317196060C2779305218 @default.
• W2317196060 hasConceptScore W2317196060C2779450455 @default.
• W2317196060 hasConceptScore W2317196060C2780007028 @default.
• W2317196060 hasConceptScore W2317196060C2987047532 @default.
• W2317196060 hasConceptScore W2317196060C55493867 @default.
• W2317196060 hasConceptScore W2317196060C71924100 @default.
• W2317196060 hasLocation W23171960601 @default.
• W2317196060 hasLocation W23171960602 @default.
• W2317196060 hasOpenAccess W2317196060 @default.
• W2317196060 hasPrimaryLocation W23171960601 @default.
• W2317196060 hasRelatedWork W1441610017 @default.
• W2317196060 hasRelatedWork W2014870504 @default.
• W2317196060 hasRelatedWork W2049779302 @default.
• W2317196060 hasRelatedWork W2107128368 @default.
• W2317196060 hasRelatedWork W2317196060 @default.
• W2317196060 hasRelatedWork W2348769845 @default.

• next