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- W2317207030 abstract "The pharmacological interaction between acutely administered ethanol and methaqualone was investigated in mice. Data were submitted to analysis of variance according to a 3 × 3 factorial design. When associated at hypnotic doses (ethanol [Formula: see text], orally, and methaqualone [Formula: see text], i.p.), both drugs lengthened sleeping time in a supraadditive manner. At lethal or near lethal doses (ethanol [Formula: see text] and methaqualone [Formula: see text]), complex interactions were observed: an antagonistic effect of ethanol (2 g/kg) against methaqualone toxicity and at least additive effects of both drugs when ethanol was given at 6 g/kg. When methaqualone was replaced by sodium barbital (725 mg/kg, i.p.) ethanol (2 g/kg) failed to exhibit any antagonistic effect. Because methaqualone at near lethal doses possesses convulsant properties, the protection afforded by ethanol (2 g/kg) might be due to its mild anticonvulsant effects. At 6 g/kg the central depressant properties of ethanol appear to be contributory to the lethality of methaqualone; in addition, at high doses, ethanol facilitates the distribution of methaqualone to the brain. This investigation suggests that the ethanol–methaqualone association induces a rather complex set of pharmacological interactions; it especially demonstrates the antagonistic properties of subhypnotic doses of ethanol against the toxicity of methaqualone." @default.
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- W2317207030 date "1980-07-01" @default.
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- W2317207030 title "Etude de l'interaction aiguë entre l'éthanol et la méthaqualone chez la souris" @default.
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- W2317207030 doi "https://doi.org/10.1139/y80-132" @default.
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