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- W2317234633 abstract "Acrolein is a toxic metabolite of the anticancer agent cyclophosphamide (CP). Current strategies to mitigate acrolein toxicity are insufficient, and in this brief article, we report the synthesis of well-defined low molecular weight block copolymers using activators generated by electron transfer atom transfer radical polymerization (AGET ATRP) capable of reacting with the cytotoxic small molecule acrolein. Acrolein reactivity was introduced into the block copolymers via incorporation of either (a) aminooxy or (b) sulfhydryl groups. The cytoprotective effect of the polymers was compared to sodium 2-sulfanylethanesulfonate (mesna) the current gold standard for protection from CP urotoxicity, and we found that the polymers bearing sulfhydryl moieties demonstrated superior cytoprotective activity." @default.
- W2317234633 created "2016-06-24" @default.
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- W2317234633 date "2015-09-21" @default.
- W2317234633 modified "2023-10-16" @default.
- W2317234633 title "Synthesis of Reactive Polymers for Acrolein Capture Using AGET ATRP" @default.
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- W2317234633 doi "https://doi.org/10.1021/acs.molpharmaceut.5b00489" @default.
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