Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317235637> ?p ?o ?g. }
- W2317235637 endingPage "1417" @default.
- W2317235637 startingPage "1409" @default.
- W2317235637 abstract "The interaction of selective estrogen receptor modulators (SERMs) with lipid membranes has been measured at clinically relevant serum concentrations using the label-free technique of second harmonic generation (SHG). The SERMs investigated in this study include raloxifene, tamoxifen, and the tamoxifen metabolites 4-hydroxytamoxifen, N-desmethyltamoxifen, and endoxifen. Equilibrium association constants (Ka) were measured for SERMs using varying lipid compositions to examine how lipid phase, packing density, and cholesterol content impact SERM-membrane interactions. Membrane-binding properties of tamoxifen and its metabolites were compared on the basis of hydroxyl group substitution and amine ionization to elucidate how the degree of drug ionization impacts membrane partitioning. SERM-membrane interactions were probed under multiple pH conditions, and drug adsorption was observed to vary with the concentration of soluble neutral species. The agreement between Ka values derived from SHG measurements of the interactions between SERMs and artificial cell membranes and independent observations of the SERMs efficacy from clinical studies suggests that quantifying membrane adsorption properties may be important for understanding SERM action in vivo." @default.
- W2317235637 created "2016-06-24" @default.
- W2317235637 creator A5016338138 @default.
- W2317235637 creator A5042189338 @default.
- W2317235637 date "2014-01-21" @default.
- W2317235637 modified "2023-10-11" @default.
- W2317235637 title "Measuring Selective Estrogen Receptor Modulator (SERM)–Membrane Interactions with Second Harmonic Generation" @default.
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