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- W2317237112 abstract "The micro- and nano-scale freezing has been a focus in many fields of scientific research and engineering practices, especially in those involved with cryobiology physics. Although a series of theoretical models and experimental techniques have been available to tackle the tough issues that associate with the freezing phase change process, the topic to quantify the ice crystal formation and its subsequent effects on the biological materials were not sufficiently addressed at all, especially when facing the newly emerging area of nano-cryobiology technology. Not only the interactions between the ice front and the cell, but also the heat and solute balance during freezing produce impact on the output of a cryosurgery or cryopreservation. There is currently a strong lack of the generalized methods which are indispensable to grasp the physical pictures from micro or nanoscale aspect and thus help achieve an intensive understanding of the mechanisms of cell damage during process of ice crystallization. This review article is dedicated to present an overview on the theoretical and experimental strategies potentially appropriate for quantifying the ice crystal formation in cryobiology area. Attentions will be focused on several major theoretical directions such as the thermodynamic theory, the kinetic theory, and the density functional theory etc., concerning the micro or nano phase change and the ice nucleation activities. Interpretation of the effects of external conditions such as freezing rate, interfacial effect, size effects, electric field and restricted space etc. on the ice growth will be given. Numerical simulation method and experimental techniques will also be outlined. The review does not intend to give an exhaustive knowledge of all the themes, but rather to provide a most basic background for further probing the emerging nano-cryobiology field and thus promote innovation in future research and practices of cryobiology." @default.
- W2317237112 created "2016-06-24" @default.
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- W2317237112 date "2010-01-01" @default.
- W2317237112 modified "2023-10-14" @default.
- W2317237112 title "Characterization of Micro-/Nano-Scale Ice Crystal Formation in Cryo-Biomedical Engineering: A Review" @default.
- W2317237112 cites W2023322002 @default.
- W2317237112 doi "https://doi.org/10.1166/jctn.2010.1334" @default.
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