Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317241925> ?p ?o ?g. }
- W2317241925 abstract "Using cellular adjuvants including dendritic cells (DCs) has provided a promising approach in immunotherapy of cancer. Our previous study showed that mice immunization with tumor cell lysate-pulsed DCs (TL-CD8α+DCs) could significantly suppress the tumor growth and increase mice survival. The aim of the present study was to investigate the impact of TL-CD8α+DC vaccine on intra-tumor and spleen lymphocyte subpopulations in tumor-bearing mice. ABalb/c mouse model of fibrosarcoma was used and changes in various lymphocyte subpopulations including CD4+, CD8+ and CD4+CD25+Foxp3+ T cells in mice immunized with TL-CD8α+ DCs were studied. The cytotoxic activity of the lymphocytes and tumor growth inhibitory rate were also measured. Immunotherapy with TL-CD8α+ DCs significantly enhanced both CD4+ and CD8+ lymphocytes, whereas decreased CD4+CD25+ Foxp3+ regulatory T cells as well as the tumor growth rate. There was also a decrease in the ratio of regulatory T cells to CD4+ and to CD8+ lymphocytes in both the tumor and spleen tissues as compared to that in the non-immunized control mice. Immunization with TL-CD8α+ DCs as well as CD8α+ DCs significantly increased the splenocytes cytotoxic activity by 45.1% and 18.2% of control, respectively. In conclusion, the current study indicated that TL-CD8α+ DCs can enhance tumor immunity against the fibrosarcoma by enhancing both the CD4+ and CD8+ lymphocytes and reducing regulatory T cells. This finding suggests the usefulness of TL-CD8α+DCs vaccine for cancer treatment." @default.
- W2317241925 created "2016-06-24" @default.
- W2317241925 creator A5000537521 @default.
- W2317241925 creator A5001475392 @default.
- W2317241925 creator A5024855394 @default.
- W2317241925 creator A5084477865 @default.
- W2317241925 creator A5086199857 @default.
- W2317241925 date "2013-01-01" @default.
- W2317241925 modified "2023-09-29" @default.
- W2317241925 title "Immunotherapy with tumor cell lysate-pulsed CD8α+ dendritic cells modulates intra-tumor and spleen lymphocyte subpopulations" @default.
- W2317241925 cites W1578357700 @default.
- W2317241925 cites W1579010799 @default.
- W2317241925 cites W1599764253 @default.
- W2317241925 cites W1755415491 @default.
- W2317241925 cites W1881253097 @default.
- W2317241925 cites W1893411048 @default.
- W2317241925 cites W1901657789 @default.
- W2317241925 cites W1933707168 @default.
- W2317241925 cites W1971439358 @default.
- W2317241925 cites W1981274926 @default.
- W2317241925 cites W1988635299 @default.
- W2317241925 cites W1991243877 @default.
- W2317241925 cites W1999031777 @default.
- W2317241925 cites W2017083690 @default.
- W2317241925 cites W2022250608 @default.
- W2317241925 cites W2022889623 @default.
- W2317241925 cites W2024914696 @default.
- W2317241925 cites W2029002400 @default.
- W2317241925 cites W2035572849 @default.
- W2317241925 cites W2041875235 @default.
- W2317241925 cites W2053925603 @default.
- W2317241925 cites W2061176964 @default.
- W2317241925 cites W2066964346 @default.
- W2317241925 cites W2070377914 @default.
- W2317241925 cites W2074792897 @default.
- W2317241925 cites W2089593668 @default.
- W2317241925 cites W2096625946 @default.
- W2317241925 cites W2098263349 @default.
- W2317241925 cites W2106934028 @default.
- W2317241925 cites W2114870968 @default.
- W2317241925 cites W2115415648 @default.
- W2317241925 cites W2128305305 @default.
- W2317241925 cites W2129980000 @default.
- W2317241925 cites W2139029604 @default.
- W2317241925 cites W2143776023 @default.
- W2317241925 cites W2144248058 @default.
- W2317241925 cites W2145888616 @default.
- W2317241925 cites W2159431217 @default.
- W2317241925 cites W2171345725 @default.
- W2317241925 cites W2411763563 @default.
- W2317241925 doi "https://doi.org/10.4149/neo_2013_068" @default.
- W2317241925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23790171" @default.
- W2317241925 hasPublicationYear "2013" @default.
- W2317241925 type Work @default.
- W2317241925 sameAs 2317241925 @default.
- W2317241925 citedByCount "2" @default.
- W2317241925 countsByYear W23172419252014 @default.
- W2317241925 countsByYear W23172419252022 @default.
- W2317241925 crossrefType "journal-article" @default.
- W2317241925 hasAuthorship W2317241925A5000537521 @default.
- W2317241925 hasAuthorship W2317241925A5001475392 @default.
- W2317241925 hasAuthorship W2317241925A5024855394 @default.
- W2317241925 hasAuthorship W2317241925A5084477865 @default.
- W2317241925 hasAuthorship W2317241925A5086199857 @default.
- W2317241925 hasBestOaLocation W23172419251 @default.
- W2317241925 hasConcept C154317977 @default.
- W2317241925 hasConcept C167672396 @default.
- W2317241925 hasConcept C189976730 @default.
- W2317241925 hasConcept C202751555 @default.
- W2317241925 hasConcept C203014093 @default.
- W2317241925 hasConcept C2776090121 @default.
- W2317241925 hasConcept C2776495794 @default.
- W2317241925 hasConcept C2777701055 @default.
- W2317241925 hasConcept C2779727006 @default.
- W2317241925 hasConcept C2780674031 @default.
- W2317241925 hasConcept C2780931953 @default.
- W2317241925 hasConcept C2992881475 @default.
- W2317241925 hasConcept C502942594 @default.
- W2317241925 hasConcept C54355233 @default.
- W2317241925 hasConcept C55493867 @default.
- W2317241925 hasConcept C79484868 @default.
- W2317241925 hasConcept C86803240 @default.
- W2317241925 hasConcept C8891405 @default.
- W2317241925 hasConceptScore W2317241925C154317977 @default.
- W2317241925 hasConceptScore W2317241925C167672396 @default.
- W2317241925 hasConceptScore W2317241925C189976730 @default.
- W2317241925 hasConceptScore W2317241925C202751555 @default.
- W2317241925 hasConceptScore W2317241925C203014093 @default.
- W2317241925 hasConceptScore W2317241925C2776090121 @default.
- W2317241925 hasConceptScore W2317241925C2776495794 @default.
- W2317241925 hasConceptScore W2317241925C2777701055 @default.
- W2317241925 hasConceptScore W2317241925C2779727006 @default.
- W2317241925 hasConceptScore W2317241925C2780674031 @default.
- W2317241925 hasConceptScore W2317241925C2780931953 @default.
- W2317241925 hasConceptScore W2317241925C2992881475 @default.
- W2317241925 hasConceptScore W2317241925C502942594 @default.
- W2317241925 hasConceptScore W2317241925C54355233 @default.
- W2317241925 hasConceptScore W2317241925C55493867 @default.
- W2317241925 hasConceptScore W2317241925C79484868 @default.
- W2317241925 hasConceptScore W2317241925C86803240 @default.