FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317248515> ?p ?o ?g. }

• W2317248515 endingPage "418" @default.
• W2317248515 startingPage "414" @default.
• W2317248515 abstract "Goal: To identify patients likely to fail metronidazole as initial treatment of C. difficile infection. Background: For moderate to severe Clostridium difficile–associated diarrhea, metronidazole is the drug of choice for treatment. Oral vancomycin is given to patients who fail metronidazole or have intolerable side effects. Study: Retrospective review identified all patients treated for C. difficile–associated diarrhea during hospitalization from January 2000 to September 2001. C difficile was documented by a positive toxin assay or pseudomembranes on colonoscopy. Metronidazole failure was defined as persistent symptoms of C. difficile–associated diarrhea after 5 days of uninterrupted therapy. Response was defined as improvement in symptoms at day 5 of therapy including reduction of diarrhea to ≤2 bowel movements per day. Results: 119 C. difficile–associated diarrhea patients were identified, and 99 met inclusion criteria. There were 61 (62%) metronidazole responders and 38 (38%) treatment failures. Albumin <2.5g/l and intensive care unit stay at/prior to diagnosis were the only variables associated with treatment failure. The odds ratios for treatment failure were 11.7 (95% confidence interval: 4.0–31.6) and 4.1 (95% confidence interval: 1.3–12.2), respectively. When considering these 2 variables together (low albumin, intensive care unit care), the area under the receiver operating characteristic curve was 0.80 for predicting treatment failure. Conclusions: Albumin level <2.5g/l and intensive care unit stay were predictors of failure of metronidazole therapy for C. difficile–associated diarrhea. These patients may benefit from oral vancomycin therapy at outset." @default.
• W2317248515 created "2016-06-24" @default.
• W2317248515 creator A5022230016 @default.
• W2317248515 creator A5037191374 @default.
• W2317248515 creator A5078049041 @default.
• W2317248515 date "2004-05-01" @default.
• W2317248515 modified "2023-09-27" @default.
• W2317248515 title "Factors Associated With Failure of Metronidazole in Clostridium difficile–associated Disease" @default.
• W2317248515 cites W1990825812 @default.
• W2317248515 cites W1991784066 @default.
• W2317248515 cites W2009061901 @default.
• W2317248515 cites W2010840061 @default.
• W2317248515 cites W2012925116 @default.
• W2317248515 cites W2025939938 @default.
• W2317248515 cites W2059695689 @default.
• W2317248515 cites W2065767371 @default.
• W2317248515 cites W2066547211 @default.
• W2317248515 cites W2080097384 @default.
• W2317248515 cites W2080394999 @default.
• W2317248515 cites W2088456526 @default.
• W2317248515 cites W2093833265 @default.
• W2317248515 cites W2123831499 @default.
• W2317248515 cites W2124167692 @default.
• W2317248515 cites W2136245438 @default.
• W2317248515 cites W2153342147 @default.
• W2317248515 cites W2160372148 @default.
• W2317248515 cites W2164612494 @default.
• W2317248515 cites W2328690882 @default.
• W2317248515 cites W2393115371 @default.
• W2317248515 cites W2588112065 @default.
• W2317248515 cites W2778801754 @default.
• W2317248515 cites W4210983716 @default.
• W2317248515 cites W4211181892 @default.
• W2317248515 cites W4254391329 @default.
• W2317248515 doi "https://doi.org/10.1097/00004836-200405000-00005" @default.
• W2317248515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15100520" @default.
• W2317248515 hasPublicationYear "2004" @default.
• W2317248515 type Work @default.
• W2317248515 sameAs 2317248515 @default.
• W2317248515 citedByCount "107" @default.
• W2317248515 countsByYear W23172485152012 @default.
• W2317248515 countsByYear W23172485152013 @default.
• W2317248515 countsByYear W23172485152014 @default.
• W2317248515 countsByYear W23172485152015 @default.
• W2317248515 countsByYear W23172485152016 @default.
• W2317248515 countsByYear W23172485152017 @default.
• W2317248515 countsByYear W23172485152018 @default.
• W2317248515 countsByYear W23172485152019 @default.
• W2317248515 countsByYear W23172485152020 @default.
• W2317248515 crossrefType "journal-article" @default.
• W2317248515 hasAuthorship W2317248515A5022230016 @default.
• W2317248515 hasAuthorship W2317248515A5037191374 @default.
• W2317248515 hasAuthorship W2317248515A5078049041 @default.
• W2317248515 hasConcept C126322002 @default.
• W2317248515 hasConcept C141071460 @default.
• W2317248515 hasConcept C156957248 @default.
• W2317248515 hasConcept C167135981 @default.
• W2317248515 hasConcept C2776258884 @default.
• W2317248515 hasConcept C2776376669 @default.
• W2317248515 hasConcept C2777396551 @default.
• W2317248515 hasConcept C2778980435 @default.
• W2317248515 hasConcept C2779489039 @default.
• W2317248515 hasConcept C2779802037 @default.
• W2317248515 hasConcept C2994496256 @default.
• W2317248515 hasConcept C44249647 @default.
• W2317248515 hasConcept C501593827 @default.
• W2317248515 hasConcept C523546767 @default.
• W2317248515 hasConcept C54355233 @default.
• W2317248515 hasConcept C71924100 @default.
• W2317248515 hasConcept C86803240 @default.
• W2317248515 hasConcept C89423630 @default.
• W2317248515 hasConcept C90924648 @default.
• W2317248515 hasConceptScore W2317248515C126322002 @default.
• W2317248515 hasConceptScore W2317248515C141071460 @default.
• W2317248515 hasConceptScore W2317248515C156957248 @default.
• W2317248515 hasConceptScore W2317248515C167135981 @default.
• W2317248515 hasConceptScore W2317248515C2776258884 @default.
• W2317248515 hasConceptScore W2317248515C2776376669 @default.
• W2317248515 hasConceptScore W2317248515C2777396551 @default.
• W2317248515 hasConceptScore W2317248515C2778980435 @default.
• W2317248515 hasConceptScore W2317248515C2779489039 @default.
• W2317248515 hasConceptScore W2317248515C2779802037 @default.
• W2317248515 hasConceptScore W2317248515C2994496256 @default.
• W2317248515 hasConceptScore W2317248515C44249647 @default.
• W2317248515 hasConceptScore W2317248515C501593827 @default.
• W2317248515 hasConceptScore W2317248515C523546767 @default.
• W2317248515 hasConceptScore W2317248515C54355233 @default.
• W2317248515 hasConceptScore W2317248515C71924100 @default.
• W2317248515 hasConceptScore W2317248515C86803240 @default.
• W2317248515 hasConceptScore W2317248515C89423630 @default.
• W2317248515 hasConceptScore W2317248515C90924648 @default.
• W2317248515 hasIssue "5" @default.
• W2317248515 hasLocation W23172485151 @default.
• W2317248515 hasLocation W23172485152 @default.
• W2317248515 hasOpenAccess W2317248515 @default.
• W2317248515 hasPrimaryLocation W23172485151 @default.
• W2317248515 hasRelatedWork W1984572269 @default.
• W2317248515 hasRelatedWork W2079539625 @default.

• next