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• W2317251434 endingPage "574" @default.
• W2317251434 startingPage "562" @default.
• W2317251434 abstract "RNAs , which play significant roles in many fundamental biological processes of life, fold into sophisticated and precise structures. RNA folding is a dynamic and intricate process, which conformation transition of coding and noncoding RNAs form the primary elements of genetic regulation. The cellular environment contains various intrinsic and extrinsic factors that potentially affect RNA folding in vivo , and experimental and theoretical evidence increasingly indicates that the highly flexible features of the RNA structure are affected by these factors, which include the flanking sequence context, physiochemical conditions, cis RNA–RNA interactions, and RNA interactions with other molecules. Furthermore, distinct RNA structures have been identified that govern almost all steps of biological processes in cells, including transcriptional activation and termination, transcriptional mutagenesis, 5′‐capping, splicing, 3′‐polyadenylation, mRNA export and localization, and translation. Here, we briefly summarize the dynamic and complex features of RNA folding along with a wide variety of intrinsic and extrinsic factors that affect RNA folding. We then provide several examples to elaborate RNA structure‐mediated regulation at the transcriptional and posttranscriptional levels. Finally, we illustrate the regulatory roles of RNA structure and discuss advances pertaining to RNA structure in plants. WIREs RNA 2016, 7:562–574. doi: 10.1002/wrna.1350 This article is categorized under: RNA Structure and Dynamics > RNA Structure, Dynamics, and Chemistry RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs" @default.
• W2317251434 created "2016-06-24" @default.
• W2317251434 creator A5012202928 @default.
• W2317251434 creator A5024830878 @default.
• W2317251434 creator A5045250047 @default.
• W2317251434 date "2016-03-29" @default.
• W2317251434 modified "2023-10-13" @default.
• W2317251434 title "Regulatory effects of cotranscriptional RNA structure formation and transitions" @default.
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• W2317251434 doi "https://doi.org/10.1002/wrna.1350" @default.
• W2317251434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27028291" @default.
• W2317251434 hasPublicationYear "2016" @default.
• W2317251434 type Work @default.

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