FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317261649> ?p ?o ?g. }

• W2317261649 abstract "You have accessJournal of UrologyPlenary I - Tuesday1 Apr 2016PI-LBA08 PRELIMINARY ASSESSMENT OF A VALIDATED URINE EXOSOME ASSAY (EXDX PROSTATE (INTELLISCORE) FOR PREDICTING BIOCHEMICAL RECURRENCE POST-PROSTATECTOMY James Eastham, Michael Donovan, Vip Patel, Vince O'Neill, Stefan Bentink, Johan Skog, and James McKiernan James EasthamJames Eastham More articles by this author , Michael DonovanMichael Donovan More articles by this author , Vip PatelVip Patel More articles by this author , Vince O'NeillVince O'Neill More articles by this author , Stefan BentinkStefan Bentink More articles by this author , Johan SkogJohan Skog More articles by this author , and James McKiernanJames McKiernan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.03.131AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Non-invasive screening tools that add predictive value for identifying high-grade, Gleason score (GS) =7 should impact on the current diagnostic and subsequent treatment decision process. We recently validated an exosomal-RNA three gene signature from first-catch, non DRE urine test (ExDx Prostate (IntelliScore) that reliably differentiates GS7+ from GS6 and benign at initial biopsy. We have also shown that this signature is associated with Gleason grade and tumor volume in the prostatectomy specimen. We sought to understand the performance of the assay in predicting disease progression post surgery. METHODS Pre-radical prostatectomy first-catch non-DRE urine specimens were collected from 3 urology practices (academic / community practices), stored at 2-8C (up to two weeks) and shipped on ice to a central laboratory (Exosome Diagnostics, St. Paul, MN). Exosomes were isolated and RNA extraction performed. RT-qPCR RNA copy numbers of ERG and PCA3 were normalized to SPDEF. Spearman and Pearson correlation along with AUC were used to evaluate performance. RESULTS Pre-RP urine samples from 359 patients were collected of which 121 had outcome data, median follow-up 2.5 years: 14% GS6, 46% GS7 (3+4), 40% (>/=GS4+3) and >85% PSA <10 ng/mL. The biochemical recurrence (BCR) rate was 19% with 23 recurrences. Applying the validated cut-point of 15.6, the ExDx Prostate (IntelliScore) assay correctly identified >90% of patients with BCR, of which 40% had an ExDx score of >55 (log-rank p value=0.39). Pre-operative PSA was predictive of BCR (p value= 0.003). Of interest, ERG RNA was not detectable in 78% of the patients with BCR. CONCLUSIONS A previously validated non-invasive urine exosome gene signature accurately reflects what is present within the prostatectomy specimen with respect to grade and tumor volume and appears to discriminate disease progression. Additional patients with extended follow-up are necessary to confirm these observations. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1071-e1072 Advertisement Copyright & Permissions© 2016MetricsAuthor Information James Eastham More articles by this author Michael Donovan More articles by this author Vip Patel More articles by this author Vince O'Neill More articles by this author Stefan Bentink More articles by this author Johan Skog More articles by this author James McKiernan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W2317261649 created "2016-06-24" @default.
• W2317261649 creator A5000622048 @default.
• W2317261649 creator A5020068745 @default.
• W2317261649 creator A5024321239 @default.
• W2317261649 creator A5025003663 @default.
• W2317261649 creator A5037449472 @default.
• W2317261649 creator A5057577594 @default.
• W2317261649 creator A5060409090 @default.
• W2317261649 date "2016-04-01" @default.
• W2317261649 modified "2023-10-15" @default.
• W2317261649 title "PI-LBA08 PRELIMINARY ASSESSMENT OF A VALIDATED URINE EXOSOME ASSAY (EXDX PROSTATE (INTELLISCORE) FOR PREDICTING BIOCHEMICAL RECURRENCE POST-PROSTATECTOMY" @default.
• W2317261649 doi "https://doi.org/10.1016/j.juro.2016.03.131" @default.
• W2317261649 hasPublicationYear "2016" @default.
• W2317261649 type Work @default.
• W2317261649 sameAs 2317261649 @default.
• W2317261649 citedByCount "1" @default.
• W2317261649 countsByYear W23172616492017 @default.
• W2317261649 crossrefType "journal-article" @default.
• W2317261649 hasAuthorship W2317261649A5000622048 @default.
• W2317261649 hasAuthorship W2317261649A5020068745 @default.
• W2317261649 hasAuthorship W2317261649A5024321239 @default.
• W2317261649 hasAuthorship W2317261649A5025003663 @default.
• W2317261649 hasAuthorship W2317261649A5037449472 @default.
• W2317261649 hasAuthorship W2317261649A5057577594 @default.
• W2317261649 hasAuthorship W2317261649A5060409090 @default.
• W2317261649 hasBestOaLocation W23172616491 @default.
• W2317261649 hasConcept C121608353 @default.
• W2317261649 hasConcept C126322002 @default.
• W2317261649 hasConcept C126894567 @default.
• W2317261649 hasConcept C2776235491 @default.
• W2317261649 hasConcept C2779466945 @default.
• W2317261649 hasConcept C2780192828 @default.
• W2317261649 hasConcept C2781217009 @default.
• W2317261649 hasConcept C2781406297 @default.
• W2317261649 hasConcept C29456083 @default.
• W2317261649 hasConcept C61434518 @default.
• W2317261649 hasConcept C71924100 @default.
• W2317261649 hasConceptScore W2317261649C121608353 @default.
• W2317261649 hasConceptScore W2317261649C126322002 @default.
• W2317261649 hasConceptScore W2317261649C126894567 @default.
• W2317261649 hasConceptScore W2317261649C2776235491 @default.
• W2317261649 hasConceptScore W2317261649C2779466945 @default.
• W2317261649 hasConceptScore W2317261649C2780192828 @default.
• W2317261649 hasConceptScore W2317261649C2781217009 @default.
• W2317261649 hasConceptScore W2317261649C2781406297 @default.
• W2317261649 hasConceptScore W2317261649C29456083 @default.
• W2317261649 hasConceptScore W2317261649C61434518 @default.
• W2317261649 hasConceptScore W2317261649C71924100 @default.
• W2317261649 hasIssue "4S" @default.
• W2317261649 hasLocation W23172616491 @default.
• W2317261649 hasOpenAccess W2317261649 @default.
• W2317261649 hasPrimaryLocation W23172616491 @default.
• W2317261649 hasRelatedWork W2042911820 @default.
• W2317261649 hasRelatedWork W2092129431 @default.
• W2317261649 hasRelatedWork W2099948048 @default.
• W2317261649 hasRelatedWork W2105000714 @default.
• W2317261649 hasRelatedWork W2152050874 @default.
• W2317261649 hasRelatedWork W2154491681 @default.
• W2317261649 hasRelatedWork W2897445903 @default.
• W2317261649 hasRelatedWork W2979919955 @default.
• W2317261649 hasRelatedWork W3087899116 @default.
• W2317261649 hasRelatedWork W93186087 @default.
• W2317261649 hasVolume "195" @default.
• W2317261649 isParatext "false" @default.
• W2317261649 isRetracted "false" @default.
• W2317261649 magId "2317261649" @default.
• W2317261649 workType "article" @default.