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• W2317286871 abstract "The scintillation proximity assay is a powerful technique for measuring radioligand binding to membrane transporters and has become an integral part of high-throughput drug discovery screening efforts. Here we adapt the method for use with purified LeuT, a prokaryotic secondary transporter, reconstituted into phospholipid bilayer nanodiscs. This application surmounts potential challenges with background interference from endogenously expressed proteins, aggregation and loss of binding activity often accompanying detergent solubilization from native cell membranes, and heterogeneity in size and transporter orientation, where at least some ligand binding sites are inaccessible, associated with reconstitution into lipid vesicles." @default.
• W2317286871 created "2016-06-24" @default.
• W2317286871 creator A5025494009 @default.
• W2317286871 creator A5071053872 @default.
• W2317286871 date "2013-12-30" @default.
• W2317286871 modified "2023-09-23" @default.
• W2317286871 title "Radioligand Binding to Nanodisc-Reconstituted Membrane Transporters Assessed by the Scintillation Proximity Assay" @default.
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• W2317286871 doi "https://doi.org/10.1021/bi401412e" @default.
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