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- W2317362904 abstract "Esophageal cancer is the 6th most common cancer worldwide. Our laboratory has used a rodent preclinical model of esophageal squamous cell carcinoma to identify putative chemopreventive agents for this disease and to determine their mechanisms of action. In our previous studies, we found an association between increased expressions of the inducible nitric oxide synthase (iNOS) and of cyclooxygenase-2 (COX-2) in the development of N-Nitrosomethylbenzylamine (NMBA)-induced tumors in the rat esophagus. We also demonstrated that S, S’-1,4-phenylene-bis(1,2-ethanediyl) bis-isothiourea (PBIT), a selective iNOS inhibitor and celecoxib, a selective COX-2 inhibitor, significantly inhibited NMBA-induced rat esophageal tumorigenesis. In view of these observations, we initiated a study to determine the combination effects of low doses of celecoxib and PBIT on progression of preneoplastic lesions to papillomas in NMBA-treated rats. F344 rats were treated with NMBA (0.30 mg/kg b.w.) three times per week for 5 weeks. After 72 hours, animals were fed AIN-76A diet or AIN-76A diet containing different doses of celecoxib, PBIT, or celecoxib plus PBIT. At week 35, rats were sacrificed and esophageal tumors were counted. The incidence of esophageal tumors was decreased from 100% in NMBA-treated rats to 96.55%, 82.76% (P Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-423." @default.
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- W2317362904 date "2010-04-15" @default.
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- W2317362904 title "Abstract LB-423: Combined chemopreventive effects of selective inducible nitric oxide synthase and cyclooxygenase-2 inhibitors onN-Nitrosomethylbenzylamine-induced rat esophageal tumorigenesis" @default.
- W2317362904 doi "https://doi.org/10.1158/1538-7445.am10-lb-423" @default.
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