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• W2317367625 abstract "The present study was to analysis the antioxidant activities of ethanolic leaves extracts of Melia azedarach Linn, Catharanthus Rosea and Brassica oleracea L.var.capitata by DPPH scavenging assay. The phytochemical screening was also carried on the leaves extracts of Melia azedarach, Catharanthus Rosea and Brassica oleracea L.var. capitata revealed the presence of some active ingredients such as Alkaloids, Tannins, Saponins, Phenols, glycosides and flavonoids.The results revealed that the ethanolic extracts of the leaves of Brassica oleracea L.var.capitata had exhibited more antioxidant activity than Catharanthus Rosea and Melia azedarach Linn. While the ethanolic leaves extract of Catharanthus Rosea had exhibited moderate antioxidant activity than other extracts. The high scavenging property of extracts may be due to hydroxyl groups existing in the phenolic compounds. INTRODUCTION Free radicals are the compounds generated from normal body processes and also from environmental pollutions. Within the human body, millions of chemical reactions are occurring constantly .These processes require oxygen. Reactive oxygen spices (ROS), sometimes called active oxygen species, are various from of activated oxygen, which include free radicals such as superoxide ions (O2 -) and hydroxyl radicals (OH-), as well as non-free-radicals species such as hydrogen peroxide (H2O2)1,2. They tend to attack the healthy cells DNA as well as proteins and fats, causing them to deteriorate. Anti-oxidants are compounds that protect cells against the damaging effects of reactive oxygen specious, such as singlet oxygen, super oxide, peroxyl radicals, hydroxyl radicals and peroxynitrite. An imbalance between antioxidants and reactive oxygen species results in oxidative stress, leading to cellular damage. Oxidative stress has linked to cancer, ageing, atherosclerosis, and ischemia injury, inflammation and neurodegenerative diseases (Parkinson’s and Alzheimer’s) 3. Catharanthus Rosea, which is commonly known as ‘periwinkle’ or ‘Vinca rosea’ belongs to family Apocynaceae and is an important source of indole alkaloids, which are present in all plant parts. The physiologically important and antineoplastic alkaloids namely Vincristine and Vinblastine are mainly present in the leaves whereas antihypertensive alkaloids such as ajmalicine, serpentine, and reserpine are reported to be present in the roots4. Vincristine and Vinblastine alkaloids are used in the treatment of various types of lymphoma and leukemia 5, 6. Melia azedarach, the Persian Lilac is popularly known as Maha neem tree and cultivated in all stations. It is a large evergreen tree found throughout India and very similar to Neem. Leaves have been shown to contain nimbinene, meliacin, quercetrin, quercetin-3-0-b-rutinoside, kaempferol3-0b rutinoside, rutin and kaempferol-3-L-rhamno-Dglucoside 7, 8. Hot methanolic etract of Melia azedarach leaves contain dipentadecyl ketone, glycerol 1,3-bis-undec-9enoate 2-dodec-9-enoate and glycerol tris-tridec-9-enoate 9 . The plant is traditionally used for the treatment of leprosy, inflammations, and cardiac disorders. Its fruits extracts possess ovicidal10 and larvicidal activity11. The leaf extracts also possess antiviral 12 and antifertility activity13 . Brassica oleracea var. capitata (Cabbage) (Family Brassicaceae) is an excellent source of vitamin C. It also contains significant amounts of glutamine, an amino acid that has antiinflammatory properties. Cabbage can also be included in dieting programs, as it is a low calorie food.The present study was directed to investigate the hepatoprotective activities of Brassica oleracea L. var. capitata against simvastatin induced hepatotoxicity. There are increasing evidences that increased consumption of fruits and vegetables and intake of certain non-nutrients that are present in foods reduce the risk of various pathological events such as cancer14, 15 and cardioand cerebro-vascular diseases 16. The vegetables are rich sources of many nutrients and antioxidant vitamins. Therefore, the objective of the present study was to determine the antioxidant activity phytochemical and in-vitro antioxidant activities f Melia azedarach Linn, Catharanthus Rosea(Vinca rosea) and Brassica oleracea L.var.capitata (Cabbage) MATERIALS and METHOD Chemicals and Reagents Folin-Ciocalteu reagent (Merck Pvt. Ltd, India), Sodium chloride (S.D. Fine Chem, India), Sodium carbonet (Merck Pvt. Ltd, India), Catechol (Himedia Lab., India), 2, 2-Diphenyle2-picryl hydrazyl (DPPH) and Vitamin C are obtained from (Himedia Lab., India).All solutions, including freshly prepared doubled distilled water. Stock solutions of the test extracts were prepared in ethanol. Appropriate blanks were used for individual assays. Plant collection and identification The plant material of Brassica oleracea var. capitata (Cabbage) ware btain from local market, while Melia azedarach Linn and Vinca rosea L obtained from Mount Opera Garden, Near Ramoji Film City, Nalgonda Dist. The plant can be identified authenticated by Department of Botany, research office (Botanist), Anwar-ulloom College of Pharmacy, Hyderabad. Extraction The leaves were dried under shade and powdered in a mechanical grinder. The powdered material (250gms) was extracted successively in Ethanol using Soxhlet apparatus at 55°C for 18 h. The extracts was concentrated in vacuo and kept in a vacuum dessicator for complete removal of solvent and weighed. Phytochemical investigation The phytochemical studies of leaves of Brassica oleracea var." @default.
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• W2317367625 title "Phytochemical and In-Vitro Antioxidant Activities of Melia azedarach Linn, Catharanthus Rosea and Bras-sica oleracea L.var.capitata" @default.
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