FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317380166> ?p ?o ?g. }

• W2317380166 endingPage "555" @default.
• W2317380166 startingPage "544" @default.
• W2317380166 abstract "The regulatory role of adenosine monophosphate-activated protein kinase (AMPK)-α 2 on sarcoplasmic reticulum calcium-ATPase (SERCA) 1a and SERCA2a in different skeletal muscle fiber types has yet to be elucidated. Sedentary (Sed) or exercise-trained (Ex) wild-type (WT) and AMPKα 2 -kinase dead (KD) transgenic mice, which overexpress a mutated and inactivated AMPKα 2 subunit, were utilized to characterize how genotype or exercise training influenced the regulation of SERCA isoforms in gastrocnemius. As expected, both Sed and Ex KD mice had >40% lower AMPK phosphorylation and 30% lower SERCA1a protein than WT mice ( P < 0.05). In contrast, SERCA2a protein was not different among KD and WT mice. Exercise increased SERCA1a and SERCA2a protein content among WT and KD mice, compared with their Sed counterparts. Maximal SERCA activity was lower in KD mice, compared with WT. Total phospholamban protein was higher in KD mice than in WT and lower in Ex compared with Sed mice. Exercise training increased phospholamban Ser 16 phosphorylation in WT mice. Laser capture microdissection and quantitative PCR indicated that SERCA1a mRNA expression among type I fibers was not altered by genotype or exercise, but SERCA2a mRNA was increased 30-fold in WT+Ex, compared with WT+Sed. In contrast, the exercise-stimulated increase for SERCA2a mRNA was blunted in KD mice. Exercise upregulated SERCA1a and SERCA2a mRNA among type II fibers, but was not altered by genotype. Collectively, these data suggest that exercise differentially influences SERCA isoform expression in type I and type II fibers. Additionally, AMPKα 2 influences the regulation of SERCA2a mRNA in type I skeletal muscle fibers following exercise training." @default.
• W2317380166 created "2016-06-24" @default.
• W2317380166 creator A5003450467 @default.
• W2317380166 creator A5038149489 @default.
• W2317380166 creator A5040639569 @default.
• W2317380166 creator A5051547215 @default.
• W2317380166 creator A5066489795 @default.
• W2317380166 creator A5067064122 @default.
• W2317380166 creator A5074826334 @default.
• W2317380166 creator A5090331546 @default.
• W2317380166 date "2014-09-01" @default.
• W2317380166 modified "2023-10-14" @default.
• W2317380166 title "Differential regulation of the fiber type-specific gene expression of the sarcoplasmic reticulum calcium-ATPase isoforms induced by exercise training" @default.
• W2317380166 cites W137375516 @default.
• W2317380166 cites W1518120013 @default.
• W2317380166 cites W1571332834 @default.
• W2317380166 cites W1944916001 @default.
• W2317380166 cites W1954023007 @default.
• W2317380166 cites W1977203311 @default.
• W2317380166 cites W1983132795 @default.
• W2317380166 cites W1994041994 @default.
• W2317380166 cites W1999655515 @default.
• W2317380166 cites W2005790553 @default.
• W2317380166 cites W2008500674 @default.
• W2317380166 cites W2013578935 @default.
• W2317380166 cites W2015171350 @default.
• W2317380166 cites W2035006932 @default.
• W2317380166 cites W2037508262 @default.
• W2317380166 cites W2041135641 @default.
• W2317380166 cites W2048859969 @default.
• W2317380166 cites W2050317198 @default.
• W2317380166 cites W2057645411 @default.
• W2317380166 cites W2059616389 @default.
• W2317380166 cites W2063301281 @default.
• W2317380166 cites W2063741674 @default.
• W2317380166 cites W2067872036 @default.
• W2317380166 cites W2068115437 @default.
• W2317380166 cites W2069107730 @default.
• W2317380166 cites W2071251209 @default.
• W2317380166 cites W2071642479 @default.
• W2317380166 cites W2079891128 @default.
• W2317380166 cites W2092854400 @default.
• W2317380166 cites W2095063450 @default.
• W2317380166 cites W2103730986 @default.
• W2317380166 cites W2104135871 @default.
• W2317380166 cites W2107277218 @default.
• W2317380166 cites W2114825009 @default.
• W2317380166 cites W2117479369 @default.
• W2317380166 cites W2120373206 @default.
• W2317380166 cites W2123352794 @default.
• W2317380166 cites W2124536446 @default.
• W2317380166 cites W2130025116 @default.
• W2317380166 cites W2131824087 @default.
• W2317380166 cites W2143251167 @default.
• W2317380166 cites W2149440213 @default.
• W2317380166 cites W2150052375 @default.
• W2317380166 cites W2150608920 @default.
• W2317380166 cites W2153872767 @default.
• W2317380166 cites W2161093611 @default.
• W2317380166 cites W2162834706 @default.
• W2317380166 cites W2163239863 @default.
• W2317380166 cites W2167357204 @default.
• W2317380166 cites W2170880090 @default.
• W2317380166 cites W2171619592 @default.
• W2317380166 cites W2180234751 @default.
• W2317380166 cites W2263966455 @default.
• W2317380166 cites W2396446279 @default.
• W2317380166 doi "https://doi.org/10.1152/japplphysiol.00092.2014" @default.
• W2317380166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4157161" @default.
• W2317380166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24876362" @default.
• W2317380166 hasPublicationYear "2014" @default.
• W2317380166 type Work @default.
• W2317380166 sameAs 2317380166 @default.
• W2317380166 citedByCount "22" @default.
• W2317380166 countsByYear W23173801662015 @default.
• W2317380166 countsByYear W23173801662016 @default.
• W2317380166 countsByYear W23173801662017 @default.
• W2317380166 countsByYear W23173801662018 @default.
• W2317380166 countsByYear W23173801662019 @default.
• W2317380166 countsByYear W23173801662020 @default.
• W2317380166 countsByYear W23173801662021 @default.
• W2317380166 countsByYear W23173801662022 @default.
• W2317380166 countsByYear W23173801662023 @default.
• W2317380166 crossrefType "journal-article" @default.
• W2317380166 hasAuthorship W2317380166A5003450467 @default.
• W2317380166 hasAuthorship W2317380166A5038149489 @default.
• W2317380166 hasAuthorship W2317380166A5040639569 @default.
• W2317380166 hasAuthorship W2317380166A5051547215 @default.
• W2317380166 hasAuthorship W2317380166A5066489795 @default.
• W2317380166 hasAuthorship W2317380166A5067064122 @default.
• W2317380166 hasAuthorship W2317380166A5074826334 @default.
• W2317380166 hasAuthorship W2317380166A5090331546 @default.
• W2317380166 hasBestOaLocation W23173801662 @default.
• W2317380166 hasConcept C11960822 @default.
• W2317380166 hasConcept C126322002 @default.
• W2317380166 hasConcept C126707884 @default.
• W2317380166 hasConcept C134018914 @default.
• W2317380166 hasConcept C17137333 @default.

• next