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- W2317389738 abstract "The mechanism of site-directed bone formation represents an important local control point in adult skeletal remodeling. The mechanism by which spatial homing signals target osteoblasts to form bone within previously resorbed lacunae have been unclear and understudied. We review the basic concepts of site-specific coupling whereby glycoproteins, such as tartrate resistant acid phosphatase (TRAP) deposited by the osteoclast within lacunae, subsequently act to direct bone formation. Osteoblast recognition domains mediating this signaling may include cell surface proteoglycans and the mannose-6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R). New techniques to study spatial coupling include in-vitro remodeling systems that characterize authentic osteoclastic lacunae, and phage display that identifies novel osteoblast receptors with affinity for lacunae. By elucidating the site-specific biological homing mechanisms that direct osteoblast activity, anabolic therapy for bone loss diseases could be developed, and allow for precise control of the location of bone formation." @default.
- W2317389738 created "2016-06-24" @default.
- W2317389738 creator A5002019608 @default.
- W2317389738 creator A5041375808 @default.
- W2317389738 creator A5072300527 @default.
- W2317389738 date "2001-10-01" @default.
- W2317389738 modified "2023-09-26" @default.
- W2317389738 title "Localization of bone formation to areas of bone resorption: osteoporosis and coupling" @default.
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- W2317389738 doi "https://doi.org/10.1097/00001433-200110000-00002" @default.
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