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• W2317435580 abstract "Event Abstract Back to Event Imaging mass spectrometry: Analysis of pharmaceutically modified biomaterials from in vitro to in vivo Anja Henß1, Marcus Rohnke1, Julia Kokesch-Himmelreich1, Peter Schmitz1, Matthias Schumacher2, Seemun Ray3, 4, Thomas Hanke5, Michael Gelinsky2, Volker Alt3, 4 and Juergen Janek1 1 Justus-Liebig-University of Giessen, Institute for Physical Chemistry, Germany 2 Technical University of Dresden, Centre for Translational Bone, Joint and Soft Tissue Research, Germany 3 University of Giessen, Laboratory of Experimental Trauma Surgery, Germany 4 University Hospital of Giessen-Marburg, Department of Trauma Surgery, Germany 5 Technical University of Dresden, Institute of Materials Science, Germany Several strategies have been developed to clinically enhance fracture healing. A promising way is to dope the implant material with pharmaceutically potent agents to facilitate a precise treatment of the diseased area. We demonstrate the potential of imaging mass spectrometry for use in the development of new bone implant materials. Time of flight secondary ion mass spectrometry (ToF-SIMS) analysis is applied to detect pharmaceutical agents and their distribution within new developed implant materials, in cells, cultured on these materials and to elucidate the release kinetics of the drugs in animal experiments. In ToF-SIMS a solid sample is bombarded by a high energetic primary ion beam. By the impact of the primary ions a wide variety of secondary particles are emitted from the top layer of the sample surface. Charged atoms and fragments, the so called secondary ions, are detected and so mass spectra are obtained. By scanning the primary ion beam, 2D mass mapping is possible. So the spatial correlation and distribution of the desorbed ions is accessible. An additional sputter gun allows material ablation and depth profiling by removing layer by layer in a small defined area. The subsequent reconstruction of the recorded data generates 3D mass images. We investigate modified calcium phosphate based cements and silica based xerogels, which have been modified with pharmaceutically potent agents. We concentrate on strontium (Sr) and bortezomib (BZ) enriched biomaterials since Sr is known to be an effective antiosteoporotic drug whereas BZ as proteasome inhibitor is used for the treatment of multiple myeloma [1]-[3]. Based on the good ionization properties of inorganic Sr, the analysis of human osteoblast-like cells cultured on the Sr-modified cements and their mineralized extracellular matrix (mECM) prove clearly, that there is an uptake of Sr into the cells as well as Sr is incorporated into the mECM [4]. Corresponding cell experiments with myeloma cells prove also the uptake of BZ into the cells but the unambiguous detection of BZ is quite more challenging. Because of its instability and its low ionization probability the detection limit is hardly reached. This is aggravated by the fact that BZ is only applied in low dose due to its cell toxic effects (in vitro) or inflammatory response (in vivo). In animal experiments the biomaterials were used to fill defects in the femur of rats. We imaged the fragments of the inorganic and organic compounds of the bone as well as the distribution of the particular drugs. Using ToF-SIMS the Sr release in the surrounding tissue is investigated and it is proven that Sr is localized in regions of newly formed bone but also within the pre-existing tissue [5]. The BZ samples showed a nearly uniform distribution of the B+/BO+ in the entire tissue and implant area. No concentration gradient of boron from the implant to the neighbored tissue was detected but rather an equal distribution with less intensity for the complete section. These findings prove the good solubility and diffusion properties of BZ but also support the assumption of a too fast degradation process of the molecule. References:[1] Schumacher M, et al., Acta Biomater. 2013;9(7):7536-44[2] Marie PJ, et al., Calcif Tissue Int. 2001;69(3):121-9.[3] Kortum KM, et al., Internist. 2013;54(8):963-75.[4] Kokesch-Himmelreich J, et al., Biointerphases. 2013;8.[5] Rohnke M, et al., Analytical and Bioanalytical Chemistry. 2013. Keywords: Drug delivery, biomedical application, Bone graft, Biodegradable material Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Imaging with biomaterials Citation: Henß A, Rohnke M, Kokesch-Himmelreich J, Schmitz P, Schumacher M, Ray S, Hanke T, Gelinsky M, Alt V and Janek J (2016). Imaging mass spectrometry: Analysis of pharmaceutically modified biomaterials from in vitro to in vivo. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01562 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Anja Henß Marcus Rohnke Julia Kokesch-Himmelreich Peter Schmitz Matthias Schumacher Seemun Ray Thomas Hanke Michael Gelinsky Volker Alt Juergen Janek Google Anja Henß Marcus Rohnke Julia Kokesch-Himmelreich Peter Schmitz Matthias Schumacher Seemun Ray Thomas Hanke Michael Gelinsky Volker Alt Juergen Janek Google Scholar Anja Henß Marcus Rohnke Julia Kokesch-Himmelreich Peter Schmitz Matthias Schumacher Seemun Ray Thomas Hanke Michael Gelinsky Volker Alt Juergen Janek PubMed Anja Henß Marcus Rohnke Julia Kokesch-Himmelreich Peter Schmitz Matthias Schumacher Seemun Ray Thomas Hanke Michael Gelinsky Volker Alt Juergen Janek Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. 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• W2317435580 title "Imaging mass spectrometry: Analysis of pharmaceutically modified biomaterials from in vitro to in vivo" @default.
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