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• W2317457936 abstract "Event Abstract Back to Event A Brief History of Research in Frontotemporal Dementia (and Celebration of Bruce Miller's Impact on it) Tiffany Chow1* 1 University of Toronto, Baycrest Rotman Research Institute, Canada Pick’s disease was first described in the 1930s. Further clinical and neuropathological information about frontotemporal dementia did not come to light until the 1970s. And since then, the frontotemporal dementias, whether one considers the behavioral or the language presentations, make a wonderful substrate for the learning objectives of this conference. They present an amazing opportunity to study the anatomy & pathophysiology of frontal lobe function & dysfunction, the expression of frontal lobe function and dysfunction across maturational stages, cover the breadth of the frontal lobe function from cognitive to emotional, and clearly show the roles of the frontal lobes in neuropsychiatric disorders. In the 60s, the Haight in San Francisco had no idea that Drs. Stan Prusiner and Bruce Miller would be on their way, setting up labs that would impact neurodegenerative disease and international collaboration to forward that research. Dementia was mostly considered to be senile dementia, and age-related phenomenon generally a tribute to hardening of the arteries. The 70s saw a handful of publications regarding presenile dementias or the odd case report about patients who would later be described as primary progressive aphasia. It was in the mid-1980s that the national Institute on aging funded the Alzheimer's Disease Research Centers. The Lund and UCLA groups introduced a new type of pathology in dementia, that of the frontotemporal type. In the 90s, things took off, with more centers around Europe and North America describing cases. Bruce Miller began to convene colleagues at Harbor-UCLA, creating his first multidisciplinary team to approach the evaluation of these patients. Family histories were examined closely, and Chromosome 17 and the region expressing tau are elucidated as playing an important role in the disease. Cortical basal syndrome, progressive supranuclear palsy, and ALS are brought into the circle of frontotemporal dementias. The next decade brought funding for multicenter data collection and broader recognition of this dementing illness by lay public. Volumetric studies cropped up like clover, but visual rating by clinicians has not yet matched the discrimination accuracy of the software. Progranulin and TAR DNA binding protein-43 were added to the list of proteinopathies associated with frontotemporal dementia. Information on mutations associated with frontotemporal dementias exceeds the proportion of Alzheimer's disease cases that have a clear genetic association. The latest decade has brought the dawning of networks approaches that map cleanly onto the distribution of von Economou neurons. Fused in sarcoma protein creates another explanation for ubiquitin immunoreactive inclusions. The Alzheimer's Disease Neuroimaging Initiative offers public access to centers with smaller populations of FTD patients to conduct their own analyses on a large uniform data set. Treatment, however, remains elusive. At best, there is symptomatic treatment. Some equal local transient behavioral benefit is noted with memantine. Clinicaltrials.gov shows 20 studies actively recruiting subjects with frontotemporal dementia. Conference: The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010. Presentation Type: Oral Presentation Topic: Symposium 8: Psychiatric Citation: Chow T (2010). A Brief History of Research in Frontotemporal Dementia (and Celebration of Bruce Miller's Impact on it). Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. doi: 10.3389/conf.fnins.2010.14.00031 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Jun 2010; Published Online: 25 Jun 2010. * Correspondence: Tiffany Chow, University of Toronto, Baycrest Rotman Research Institute, Toronto, Canada, tchow@rotman-baycrest.on.ca Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Tiffany Chow Google Tiffany Chow Google Scholar Tiffany Chow PubMed Tiffany Chow Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2317457936 title "A Brief History of Research in Frontotemporal Dementia (and Celebration of Bruce Miller's Impact on it)" @default.
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