Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317458673> ?p ?o ?g. }
- W2317458673 endingPage "787" @default.
- W2317458673 startingPage "779" @default.
- W2317458673 abstract "Abstract Racial/ethnic disparity in prostate cancer is under studied in men with diabetes who are at a higher risk of aggressive prostate cancer. This study assessed the race/ethnic disparity in prostate cancer incidence for men with type II diabetes (T2D) and whether the impact of metformin on prostate cancer incidence varied by race/ethnicity. We conducted a retrospective study in 76,733 male veterans with T2D during 2003 to 2012. Cox proportional hazards model adjusting for covariates and propensity scores of metformin use and race/ethnic group membership was utilized to compute the HR of prostate cancer incidence associated with race/ethnicity and compare HR associated with metformin use between race/ethnic groups. Mean follow-up was 6.4 ± 2.8 years; 7% were Hispanics; 17% were African Americans (AA); mean age was 67.8 ± 9.8 years; 5.2% developed prostate cancer; and 38.9% used metformin. Among these diabetic men without metformin use, prostate cancer incidence was higher in Hispanics and AA than in non-Hispanic White (NHW). Use of metformin alone or metformin + statins was associated with a greater prostate cancer incidence reduction in Hispanics compared with NHW, but not between AA and NHW. Use of metformin + finasteride was associated with a greater prostate cancer incidence reduction in Hispanics and AA compared with NHW. Our results suggested that metformin treatment could be a potential strategy to reduce prostate cancer incidence in the minority populations who are at high risk for fatal prostate cancer. It will be important to further examine the pleiotropic effects of metformin in multi-race/ethnic prospective studies to better inform clinical management and potentially reduce racial/ethnic disparity in prostate cancer incidence among diabetic men. Cancer Prev Res; 9(10); 779–87. ©2016 AACR." @default.
- W2317458673 created "2016-06-24" @default.
- W2317458673 creator A5001314462 @default.
- W2317458673 creator A5004814161 @default.
- W2317458673 creator A5006883852 @default.
- W2317458673 creator A5009108510 @default.
- W2317458673 creator A5009827705 @default.
- W2317458673 creator A5015887484 @default.
- W2317458673 creator A5023001389 @default.
- W2317458673 creator A5042612191 @default.
- W2317458673 creator A5056502629 @default.
- W2317458673 creator A5064807501 @default.
- W2317458673 creator A5069037609 @default.
- W2317458673 creator A5075492015 @default.
- W2317458673 date "2016-10-01" @default.
- W2317458673 modified "2023-09-25" @default.
- W2317458673 title "Metformin for Reducing Racial/Ethnic Difference in Prostate Cancer Incidence for Men with Type II Diabetes" @default.
- W2317458673 cites W1490698620 @default.
- W2317458673 cites W1963561992 @default.
- W2317458673 cites W1964838116 @default.
- W2317458673 cites W1968008268 @default.
- W2317458673 cites W1970974137 @default.
- W2317458673 cites W2020211472 @default.
- W2317458673 cites W2025859849 @default.
- W2317458673 cites W2029669938 @default.
- W2317458673 cites W2035074239 @default.
- W2317458673 cites W2039745512 @default.
- W2317458673 cites W2059116757 @default.
- W2317458673 cites W2065739428 @default.
- W2317458673 cites W2091853487 @default.
- W2317458673 cites W2110289717 @default.
- W2317458673 cites W2117938858 @default.
- W2317458673 cites W2119551822 @default.
- W2317458673 cites W2121413852 @default.
- W2317458673 cites W2123846587 @default.
- W2317458673 cites W2129168200 @default.
- W2317458673 cites W2130944773 @default.
- W2317458673 cites W2136670934 @default.
- W2317458673 cites W2137393786 @default.
- W2317458673 cites W2137586574 @default.
- W2317458673 cites W2143501475 @default.
- W2317458673 cites W2146780639 @default.
- W2317458673 cites W2149179641 @default.
- W2317458673 cites W2150291618 @default.
- W2317458673 cites W2152817207 @default.
- W2317458673 cites W2153996274 @default.
- W2317458673 cites W2158916292 @default.
- W2317458673 cites W2165948908 @default.
- W2317458673 cites W2169214947 @default.
- W2317458673 cites W255900631 @default.
- W2317458673 cites W2560470322 @default.
- W2317458673 cites W3135529189 @default.
- W2317458673 cites W4362207783 @default.
- W2317458673 doi "https://doi.org/10.1158/1940-6207.capr-15-0425" @default.
- W2317458673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5042809" @default.
- W2317458673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27026681" @default.
- W2317458673 hasPublicationYear "2016" @default.
- W2317458673 type Work @default.
- W2317458673 sameAs 2317458673 @default.
- W2317458673 citedByCount "20" @default.
- W2317458673 countsByYear W23174586732016 @default.
- W2317458673 countsByYear W23174586732018 @default.
- W2317458673 countsByYear W23174586732019 @default.
- W2317458673 countsByYear W23174586732020 @default.
- W2317458673 countsByYear W23174586732021 @default.
- W2317458673 countsByYear W23174586732022 @default.
- W2317458673 countsByYear W23174586732023 @default.
- W2317458673 crossrefType "journal-article" @default.
- W2317458673 hasAuthorship W2317458673A5001314462 @default.
- W2317458673 hasAuthorship W2317458673A5004814161 @default.
- W2317458673 hasAuthorship W2317458673A5006883852 @default.
- W2317458673 hasAuthorship W2317458673A5009108510 @default.
- W2317458673 hasAuthorship W2317458673A5009827705 @default.
- W2317458673 hasAuthorship W2317458673A5015887484 @default.
- W2317458673 hasAuthorship W2317458673A5023001389 @default.
- W2317458673 hasAuthorship W2317458673A5042612191 @default.
- W2317458673 hasAuthorship W2317458673A5056502629 @default.
- W2317458673 hasAuthorship W2317458673A5064807501 @default.
- W2317458673 hasAuthorship W2317458673A5069037609 @default.
- W2317458673 hasAuthorship W2317458673A5075492015 @default.
- W2317458673 hasBestOaLocation W23174586731 @default.
- W2317458673 hasConcept C120665830 @default.
- W2317458673 hasConcept C121332964 @default.
- W2317458673 hasConcept C121608353 @default.
- W2317458673 hasConcept C126322002 @default.
- W2317458673 hasConcept C134018914 @default.
- W2317458673 hasConcept C143998085 @default.
- W2317458673 hasConcept C2776235491 @default.
- W2317458673 hasConcept C2777180221 @default.
- W2317458673 hasConcept C2780192828 @default.
- W2317458673 hasConcept C2780323712 @default.
- W2317458673 hasConcept C29456083 @default.
- W2317458673 hasConcept C555293320 @default.
- W2317458673 hasConcept C61511704 @default.
- W2317458673 hasConcept C71924100 @default.
- W2317458673 hasConceptScore W2317458673C120665830 @default.
- W2317458673 hasConceptScore W2317458673C121332964 @default.
- W2317458673 hasConceptScore W2317458673C121608353 @default.