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• W2317460462 abstract "ContextUnderstanding the risk of human immunodeficiency virus (HIV) transmissionthrough breastfeeding is essential for advising HIV-infected mothers and formulatingpublic health policy recommendations.ObjectiveTo measure the frequency, timing, and risk factors of HIV transmissionthrough breast milk.DesignProspective cohort study conducted between 1994 and 1997, with follow-upof infants through 24 months of age.SettingPostnatal clinic of tertiary care hospital, Blantyre, Malawi.ParticipantsA total of 672 infants (HIV-negative at birth) born to HIV-infectedwomen who had not received antiretroviral drugs during or after pregnancy.Main Outcome MeasureIncidence of HIV in breastfed infants by age and maternal and infantrisk factors for HIV transmission, using proportional hazard models to deriverisk ratios (RRs) and 95% confidence intervals (CIs).ResultsForty-seven children became HIV-infected while breastfeeding but noneafter breastfeeding had stopped. The cumulative infection rate while breastfeeding,from month 1 to the end of months 5, 11, 17, and 23, was 3.5%, 7.0%, 8.9%,and 10.3%, respectively. Incidence per month was 0.7% during age 1 to 5 months,0.6% during age 6 to 11 months, and 0.3% during age 12 to 17 months (P=.01 for trend). The only factors significantly associatedwith low risk of postnatal HIV transmission in a multivariate model were highmaternal parity (RR, 0.23; 95% CI, 0.09-0.56) and older maternal age (RR,0.44; 95% CI, 0.23-0.84).ConclusionsOur data suggest that the risk of HIV infection is highest in the earlymonths of breastfeeding, which should be considered in formulating breastfeedingpolicy recommendations." @default.
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• W2317460462 date "2000-03-01" @default.
• W2317460462 modified "2023-09-26" @default.
• W2317460462 title "HIV Transmission Through Breastfeeding: A Study in Malawi" @default.
• W2317460462 doi "https://doi.org/10.1097/00006254-200003000-00011" @default.
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