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- W2317473625 abstract "In recent years the incidence of opportunistic fungus infections has extraordinarily increased. Of the total of 716 autopsy cases performed during the ten-year period from 1975 to 1984 at the 2nd Department of Pathology, Shinshu University School of Medicine, fungus infections were present in 104 cases (14.56%). However, there was no annual increase in them during this period. The rate of fatal infections in this series was higher than that in other reports.The results of histopathological examination of the 104 cases and experimental studies using Candida albicans, Aspergillus fumigatus, Rhizopus oryzae, Fusarium oxysporum and Cryptococcus neoformans were as follows:1. Various antecedent lesions were frequently found on the skin, mucosa of inner organs and in the lungs, hematopoietic organs, liver, kidneys and endocrine organs which allowed the causative fungi to enter the tissues.2. Fungi inoculated into rabbits were initially eliminated by polymorphonuclear leukocytes and macrophages. Therefore, the functional disturbances of these cells are principal in the development of opportunistic fungus infections and neither humoral nor cell-mediated immunity plays a role in eliminating opportunistic fungi at the early stage.3. Tissue lesions in opportunistic fungus infections are suppurative, granulomatous, necrotizing or non-reactive, corresponding to various states of defense mechanism of hosts.4. Organ affinity of the causative fungi disappears in severe opportunistic infections." @default.
- W2317473625 created "2016-06-24" @default.
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- W2317473625 date "1986-01-01" @default.
- W2317473625 modified "2023-09-28" @default.
- W2317473625 title "Pathological Aspects of Opportunistic Fungus Infections" @default.
- W2317473625 cites W1502718082 @default.
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- W2317473625 doi "https://doi.org/10.3314/jjmm1960.27.86" @default.
- W2317473625 hasPublicationYear "1986" @default.
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