Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317482803> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2317482803 endingPage "128" @default.
- W2317482803 startingPage "123" @default.
- W2317482803 abstract "Although patients with Fanconi's anaemia (FA) exhibit a heightened sensitivity to DNA cross-linking agents, modified doses of CY continue to be used in their conditioning prior to BMT. We measured the pharmacokinetics and metabolism of CY in six children with FA using an established high performance thin layer chromatography technique. CY doses ranged between 5 and 20 mg/kg (median 10 mg/kg). The median CY clearance was 0.6 l/h/m2 (range 0.4-1.1 l/h/m2), t1/2 was 8.1 h (range 6.7-9.5 h) and volume of distribution was 0.19 l/kg (range 0.16-0.34 l/kg), respectively. These results contrast with those previously reported from a comparable group of non-FA children in whom the median CY clearance was 3.2 l/h/m2 (range 2-5 l/h/m2) (P = 0.035), t1/2 was 2.4 h (range 2-3.8 h) (P = 0.035) and volume of distribution 0.5 l/kg (range 0.26-0.95 l/kg) (NS). Unlike the control group in whom the presence of inactive metabolites of CY was common, metabolites could not be found in any FA patient. The enhanced sensitivity of children with FA to CY may in part result from altered drug metabolism." @default.
- W2317482803 created "2016-06-24" @default.
- W2317482803 creator A5000430881 @default.
- W2317482803 creator A5013139347 @default.
- W2317482803 creator A5015020848 @default.
- W2317482803 creator A5032716539 @default.
- W2317482803 creator A5052706160 @default.
- W2317482803 date "1999-07-01" @default.
- W2317482803 modified "2023-10-06" @default.
- W2317482803 title "Cyclophosphamide metabolism in children with Fanconi’s anaemia" @default.
- W2317482803 doi "https://doi.org/10.1038/sj.bmt.1701868" @default.
- W2317482803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10455339" @default.
- W2317482803 hasPublicationYear "1999" @default.
- W2317482803 type Work @default.
- W2317482803 sameAs 2317482803 @default.
- W2317482803 citedByCount "15" @default.
- W2317482803 countsByYear W23174828032012 @default.
- W2317482803 countsByYear W23174828032021 @default.
- W2317482803 countsByYear W23174828032023 @default.
- W2317482803 crossrefType "journal-article" @default.
- W2317482803 hasAuthorship W2317482803A5000430881 @default.
- W2317482803 hasAuthorship W2317482803A5013139347 @default.
- W2317482803 hasAuthorship W2317482803A5015020848 @default.
- W2317482803 hasAuthorship W2317482803A5032716539 @default.
- W2317482803 hasAuthorship W2317482803A5052706160 @default.
- W2317482803 hasBestOaLocation W23174828031 @default.
- W2317482803 hasConcept C112705442 @default.
- W2317482803 hasConcept C126322002 @default.
- W2317482803 hasConcept C134018914 @default.
- W2317482803 hasConcept C139254425 @default.
- W2317482803 hasConcept C2776694085 @default.
- W2317482803 hasConcept C2776755627 @default.
- W2317482803 hasConcept C62231903 @default.
- W2317482803 hasConcept C71924100 @default.
- W2317482803 hasConcept C90924648 @default.
- W2317482803 hasConceptScore W2317482803C112705442 @default.
- W2317482803 hasConceptScore W2317482803C126322002 @default.
- W2317482803 hasConceptScore W2317482803C134018914 @default.
- W2317482803 hasConceptScore W2317482803C139254425 @default.
- W2317482803 hasConceptScore W2317482803C2776694085 @default.
- W2317482803 hasConceptScore W2317482803C2776755627 @default.
- W2317482803 hasConceptScore W2317482803C62231903 @default.
- W2317482803 hasConceptScore W2317482803C71924100 @default.
- W2317482803 hasConceptScore W2317482803C90924648 @default.
- W2317482803 hasIssue "2" @default.
- W2317482803 hasLocation W23174828031 @default.
- W2317482803 hasLocation W23174828032 @default.
- W2317482803 hasOpenAccess W2317482803 @default.
- W2317482803 hasPrimaryLocation W23174828031 @default.
- W2317482803 hasRelatedWork W1524016106 @default.
- W2317482803 hasRelatedWork W1966504330 @default.
- W2317482803 hasRelatedWork W1978954584 @default.
- W2317482803 hasRelatedWork W1979139803 @default.
- W2317482803 hasRelatedWork W1985608818 @default.
- W2317482803 hasRelatedWork W1992836784 @default.
- W2317482803 hasRelatedWork W2041949500 @default.
- W2317482803 hasRelatedWork W2058385006 @default.
- W2317482803 hasRelatedWork W2089460504 @default.
- W2317482803 hasRelatedWork W2748952813 @default.
- W2317482803 hasVolume "24" @default.
- W2317482803 isParatext "false" @default.
- W2317482803 isRetracted "false" @default.
- W2317482803 magId "2317482803" @default.
- W2317482803 workType "article" @default.