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• W2317492730 endingPage "200" @default.
• W2317492730 startingPage "200" @default.
• W2317492730 abstract "Summary: Little is known about the role of the tonsils in HTLV-I infection. We performed molecular pathologic studies of tonsils in individuals positive or negative for anti-HTLV-I antibodies (HTLV-I-Ab) to clarify histologic characteristics of tonsils in HTLV-I infection. We collected tonsils and peripheral blood samples from patients who underwent tonsillectomy in a prospective manner. HTLV-I-Ab in serum was examined and presence of HTLV-I provirus was detected by polymerase chain reaction (PCR) in extracted DNA of both peripheral blood and tonsils. Histopathologic and immunohistochemical evaluations of tonsils were performed. HTLV-I seropositivity and PCR detection of HTLV-I provirus matched perfectly. Tonsil samples from seropositive individuals showed atrophy of the mantle zone and high numbers of T cells in the marginal zone compared with findings in HTLV-I-negative samples. HTLV-I provirus could be detected only from extracted DNA of extrafollicular areas. PCR in situ hybridization also showed positive signals in some mononuclear cells located in the marginal zone. There was a significant correlation between HTLV-I proviral load in tonsils and in peripheral blood. These results suggest the presence of characteristic histologic changes and deviated localization of HTLV-I-infected cells in the tonsils of individuals positive for HTLV-I." @default.
• W2317492730 created "2016-06-24" @default.
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• W2317492730 date "1999-10-01" @default.
• W2317492730 modified "2023-09-25" @default.
• W2317492730 title "Molecular Pathologic Analysis of the Tonsil in HTLV-I–Infected Individuals" @default.
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• W2317492730 doi "https://doi.org/10.1097/00126334-199910010-00014" @default.
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