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• W2317496870 abstract "There is now abundant evidence that the continuous accumulation of deleterious mutations within natural populations poses a major problem for neo-Darwinian theory. It has been proposed that a viable evolutionary mechanism for halting the accumulation of deleterious mutations might arise if fitness depends primarily on an individual’s “mutation-count”. In this paper the hypothetical “ mutation-count mechanism” (MCM) is tested using numerical simulation, to determine the viability of the hypothesis and to determine what biological factors affect the relative efficacy of this mechanism. The MCM is shown to be very strong when given all the following un-natural conditions: all mutations have an equal effect, low environmental variance, and full truncation selection. Conversely, the MCM effect essentially disappears given any of the following natural conditions: asexual reproduction, or probability selection, or accumulating mutations having a natural distribution of fitness effects covering several orders of magnitude. Realistic levels of environmental variance can also abolish or greatly diminish the MCM effect. Equal mutation effects when combined with partial truncation (quasi-truncation) can create a moderate MCM effect, but this disappears in the presence of less uniform mutation effects and reasonable levels of environmental variance. MCM does not appear to occur under most biologically realistic conditions, and so is not a generally applicable evolutionary mechanism. MCM is not generally capable of stopping deleterious mutation accumulation in most natural populations." @default.
• W2317496870 created "2016-06-24" @default.
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• W2317496870 date "2013-05-31" @default.
• W2317496870 modified "2023-09-26" @default.
• W2317496870 title "Using Numerical Simulation to Test the “Mutation-Count” Hypothesis" @default.
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• W2317496870 doi "https://doi.org/10.1142/9789814508728_0012" @default.
• W2317496870 hasPublicationYear "2013" @default.
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