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• W2317505741 endingPage "9565" @default.
• W2317505741 startingPage "9554" @default.
• W2317505741 abstract "Microneme secretion is essential for motility, invasion, and egress in apicomplexan parasites. Although previous studies indicate that Ca(2+) and cGMP control microneme secretion, little is known about how these pathways are naturally activated. Here we have developed genetically encoded indicators for Ca(2+) and microneme secretion to better define the signaling pathways that regulate these processes in Toxoplasma gondii We found that microneme secretion was triggered in vitro by exposure to a single host protein, serum albumin. The natural agonist serum albumin induced microneme secretion in a protein kinase G-dependent manner that correlated with increased cGMP levels. Surprisingly, serum albumin acted independently of elevated Ca(2+) and yet it was augmented by artificial agonists that raise Ca(2+), such as ethanol. Furthermore, although ethanol elevated intracellular Ca(2+), it alone was unable to trigger secretion without the presence of serum or serum albumin. This dichotomy was recapitulated by zaprinast, a phosphodiesterase inhibitor that elevated cGMP and separately increased Ca(2+) in a protein kinase G-independent manner leading to microneme secretion. Taken together, these findings reveal that microneme secretion is centrally controlled by protein kinase G and that this pathway is further augmented by elevation of intracellular Ca(2.)" @default.
• W2317505741 created "2016-06-24" @default.
• W2317505741 creator A5031443037 @default.
• W2317505741 creator A5042957984 @default.
• W2317505741 creator A5076412046 @default.
• W2317505741 date "2016-04-01" @default.
• W2317505741 modified "2023-10-12" @default.
• W2317505741 title "Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii" @default.
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• W2317505741 doi "https://doi.org/10.1074/jbc.m115.700518" @default.
• W2317505741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4850294" @default.
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• W2317505741 hasPublicationYear "2016" @default.
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