FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317505937> ?p ?o ?g. }

• W2317505937 endingPage "265" @default.
• W2317505937 startingPage "259" @default.
• W2317505937 abstract "The peroxidase activity of cytochrome c may play a key role in the release of cytochrome c from the mitochondrial intermembrane space in the intrinsic apoptosis pathway. Induction of the peroxidase activity of cytochrome c is ascribed to partial unfolding and loss of axial co-ordination between the haem Fe and Met80, and is thought to be triggered by interaction of cytochrome c with cardiolipin (diphosphatidylglycerol) in vivo. However, the reaction mechanism for the peroxidase activity of either native or cardiolipin-bound cytochrome c is uncertain. In the present study we analyse the peroxidase activity of human and mouse cytochrome c residue 41 variants and demonstrate that stimulation of peroxidase activity can occur without prior loss of Fe-Met80 co-ordination or partial unfolding. The effects of cardiolipin and mutation of residue 41 are not additive, suggesting that cardiolipin stimulates peroxidase activity by the same mechanism as residue 41 mutation. Consistent with this, mutation of residue 41 did not enhance apoptotic release of cytochrome c from mitochondria. We propose that mutation of residue 41, and interaction with cardiolipin, increase peroxidase activity by altering the 40-57 Ω loop and its hydrogen bond network with the propionate of haem ring A. These changes enhance access of hydrogen peroxide and substrate to the haem." @default.
• W2317505937 created "2016-06-24" @default.
• W2317505937 creator A5023529487 @default.
• W2317505937 creator A5046630896 @default.
• W2317505937 creator A5055773053 @default.
• W2317505937 creator A5064931533 @default.
• W2317505937 creator A5076901371 @default.
• W2317505937 date "2014-02-14" @default.
• W2317505937 modified "2023-10-09" @default.
• W2317505937 title "Enhancing the peroxidase activity of cytochrome <i>c</i> by mutation of residue 41: implications for the peroxidase mechanism and cytochrome <i>c</i> release" @default.
• W2317505937 cites W147247410 @default.
• W2317505937 cites W1491243950 @default.
• W2317505937 cites W1507812324 @default.
• W2317505937 cites W1514650462 @default.
• W2317505937 cites W1523220226 @default.
• W2317505937 cites W1551289009 @default.
• W2317505937 cites W1977914031 @default.
• W2317505937 cites W1980199670 @default.
• W2317505937 cites W1991455654 @default.
• W2317505937 cites W1992077396 @default.
• W2317505937 cites W1997970837 @default.
• W2317505937 cites W1999445282 @default.
• W2317505937 cites W2002088627 @default.
• W2317505937 cites W2002621746 @default.
• W2317505937 cites W2004693594 @default.
• W2317505937 cites W2005441809 @default.
• W2317505937 cites W2007130017 @default.
• W2317505937 cites W2010156318 @default.
• W2317505937 cites W2012553260 @default.
• W2317505937 cites W2013091489 @default.
• W2317505937 cites W2013363343 @default.
• W2317505937 cites W2015767083 @default.
• W2317505937 cites W2019746191 @default.
• W2317505937 cites W2021528199 @default.
• W2317505937 cites W2029877800 @default.
• W2317505937 cites W2031764760 @default.
• W2317505937 cites W2037885048 @default.
• W2317505937 cites W2048649216 @default.
• W2317505937 cites W2048686528 @default.
• W2317505937 cites W2051074280 @default.
• W2317505937 cites W2052401089 @default.
• W2317505937 cites W2062730505 @default.
• W2317505937 cites W2062897750 @default.
• W2317505937 cites W2076432917 @default.
• W2317505937 cites W2086142700 @default.
• W2317505937 cites W2090782332 @default.
• W2317505937 cites W2109683405 @default.
• W2317505937 cites W2122028337 @default.
• W2317505937 cites W2144332174 @default.
• W2317505937 cites W2149161813 @default.
• W2317505937 cites W2162390197 @default.
• W2317505937 cites W2166278725 @default.
• W2317505937 cites W2334880336 @default.
• W2317505937 cites W4232534952 @default.
• W2317505937 cites W4238598813 @default.
• W2317505937 doi "https://doi.org/10.1042/bj20131386" @default.
• W2317505937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24329121" @default.
• W2317505937 hasPublicationYear "2014" @default.
• W2317505937 type Work @default.
• W2317505937 sameAs 2317505937 @default.
• W2317505937 citedByCount "35" @default.
• W2317505937 countsByYear W23175059372015 @default.
• W2317505937 countsByYear W23175059372016 @default.
• W2317505937 countsByYear W23175059372017 @default.
• W2317505937 countsByYear W23175059372018 @default.
• W2317505937 countsByYear W23175059372019 @default.
• W2317505937 countsByYear W23175059372020 @default.
• W2317505937 countsByYear W23175059372021 @default.
• W2317505937 countsByYear W23175059372023 @default.
• W2317505937 crossrefType "journal-article" @default.
• W2317505937 hasAuthorship W2317505937A5023529487 @default.
• W2317505937 hasAuthorship W2317505937A5046630896 @default.
• W2317505937 hasAuthorship W2317505937A5055773053 @default.
• W2317505937 hasAuthorship W2317505937A5064931533 @default.
• W2317505937 hasAuthorship W2317505937A5076901371 @default.
• W2317505937 hasConcept C133166286 @default.
• W2317505937 hasConcept C14471203 @default.
• W2317505937 hasConcept C162008176 @default.
• W2317505937 hasConcept C181199279 @default.
• W2317505937 hasConcept C185592680 @default.
• W2317505937 hasConcept C2778918659 @default.
• W2317505937 hasConcept C2780768313 @default.
• W2317505937 hasConcept C2781302388 @default.
• W2317505937 hasConcept C28859421 @default.
• W2317505937 hasConcept C29311851 @default.
• W2317505937 hasConcept C41625074 @default.
• W2317505937 hasConcept C55493867 @default.
• W2317505937 hasConcept C71240020 @default.
• W2317505937 hasConceptScore W2317505937C133166286 @default.
• W2317505937 hasConceptScore W2317505937C14471203 @default.
• W2317505937 hasConceptScore W2317505937C162008176 @default.
• W2317505937 hasConceptScore W2317505937C181199279 @default.
• W2317505937 hasConceptScore W2317505937C185592680 @default.
• W2317505937 hasConceptScore W2317505937C2778918659 @default.
• W2317505937 hasConceptScore W2317505937C2780768313 @default.
• W2317505937 hasConceptScore W2317505937C2781302388 @default.
• W2317505937 hasConceptScore W2317505937C28859421 @default.
• W2317505937 hasConceptScore W2317505937C29311851 @default.

• next