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- W2317520107 abstract "2007年9月から2012年5月にBevacizumab（以下BV）併用化学療法を施行した進行・再発大腸癌228例中，消化管穿孔は6例（2.6％）に認めた．症状出現から診断までは6-244時間（中央値85）で，軽度な腹部症状で発症し，全例独歩来院であった．全例手術治療を行い，5例は軽快退院，1例は腹膜炎の軽快後原疾患増悪にて21日目に死亡した．2例で創傷治癒遅延を認めたが，重篤な合併症は認めなかった．穿孔原因は憩室，多発潰瘍，播種細胞破綻等であった．原発巣の穿孔症例はなかった．今回の検討では，BV関連消化管穿孔は発症時の症状は軽微，かつ全身状態は比較的良好で，診断に至るまで長時間を要していた．全例手術を行い良好な結果が得られた．担癌，化学療法中であるが手術リスクが極めて高いとは言えず，外科的治療を迅速に行うべきと考えられた．" @default.
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- W2317520107 date "2013-01-01" @default.
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- W2317520107 title "Clinicopathological features of bevacizumab-related gastrointestinal perforation in patients with advanced colorectal cancer" @default.
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