FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317521207> ?p ?o ?g. }

• W2317521207 endingPage "1518" @default.
• W2317521207 startingPage "1518" @default.
• W2317521207 abstract "To investigate the distribution and expression of C-type natriuretic peptide (CNP)/natriuretic peptide receptor B (NPR-B) in the rectum of a rodent depression model and the interventional effect of Xiaoyaosan (XYS).Male rats (n = 45) of clean grade (200 ± 20 g) were divided into five groups after one week of adaptive feeding: primary control, depression model, low dose XYS, middle dose XYS, and high dose XYS. The animal experiment continued for 3 wk. Primary controls were fed normally ad libitum. The rats of all other groups were raised in solitary and exposed to classic chronic mild unpredictable stimulation each day. XYS groups were perfused intragastrically with low dose, middle dose, and high dose XYS one hour before stimulation. Primary control and depression model groups were perfused intragastrically with normal saline under similar conditions as the XYS groups. Three weeks later, all rats were sacrificed, and the expression levels of CNP and NPR-B in rectum tissues were analyzed by immunohistochemistry, real-time polymerase chain reaction, and Western blotting.CNP and NPR-B were both expressed in the rectum tissues of all rats. However, the expression levels of CNP and NPR-B at both gene and protein levels in the depression model group were significantly higher when compared to the primary control group (n = 9; P < 0.01). XYS intervention markedly inhibited the expression levels of CNP and NPR-B in depressed rats. The expression levels of CNP and NPR-B in the high dose XYS group did not significantly differ from the expression levels in the primary control group. Additionally, the high and middle dose XYS groups (but not the low dose group) significantly exhibited lower CNP and NPR-B expression levels in the rectum tissues of the respectively treated rats compared to the untreated depression model cohort (n = 9; P < 0.01).The CNP/NPR-B pathway is upregulated in the rectum of depressed rats and may be one mechanism for depression-associated digestive disorders. XYS antagonizes this pathway at least partially." @default.
• W2317521207 created "2016-06-24" @default.
• W2317521207 creator A5019620793 @default.
• W2317521207 date "2015-01-01" @default.
• W2317521207 modified "2023-09-23" @default.
• W2317521207 title "CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan" @default.
• W2317521207 cites W1517389358 @default.
• W2317521207 cites W1584351787 @default.
• W2317521207 cites W1591183789 @default.
• W2317521207 cites W1892403428 @default.
• W2317521207 cites W1968058596 @default.
• W2317521207 cites W1977387337 @default.
• W2317521207 cites W1980217653 @default.
• W2317521207 cites W1982121289 @default.
• W2317521207 cites W1984238092 @default.
• W2317521207 cites W1989621039 @default.
• W2317521207 cites W1993623582 @default.
• W2317521207 cites W2001115693 @default.
• W2317521207 cites W2010484522 @default.
• W2317521207 cites W2011470488 @default.
• W2317521207 cites W2011816955 @default.
• W2317521207 cites W2011914193 @default.
• W2317521207 cites W2015237383 @default.
• W2317521207 cites W2023174233 @default.
• W2317521207 cites W2028836004 @default.
• W2317521207 cites W2029768157 @default.
• W2317521207 cites W2033353801 @default.
• W2317521207 cites W2040844567 @default.
• W2317521207 cites W2045952607 @default.
• W2317521207 cites W2047232138 @default.
• W2317521207 cites W2052788006 @default.
• W2317521207 cites W2053797333 @default.
• W2317521207 cites W2057337944 @default.
• W2317521207 cites W2091136203 @default.
• W2317521207 cites W2099390687 @default.
• W2317521207 cites W2099455855 @default.
• W2317521207 cites W2102099714 @default.
• W2317521207 cites W2112056329 @default.
• W2317521207 cites W2125035146 @default.
• W2317521207 cites W2163286994 @default.
• W2317521207 cites W2163645296 @default.
• W2317521207 cites W2181446882 @default.
• W2317521207 cites W2406588687 @default.
• W2317521207 cites W2407070909 @default.
• W2317521207 cites W39026146 @default.
• W2317521207 cites W55097559 @default.
• W2317521207 cites W62438130 @default.
• W2317521207 doi "https://doi.org/10.3748/wjg.v21.i5.1518" @default.
• W2317521207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4316094" @default.
• W2317521207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25663771" @default.
• W2317521207 hasPublicationYear "2015" @default.
• W2317521207 type Work @default.
• W2317521207 sameAs 2317521207 @default.
• W2317521207 citedByCount "15" @default.
• W2317521207 countsByYear W23175212072016 @default.
• W2317521207 countsByYear W23175212072017 @default.
• W2317521207 countsByYear W23175212072019 @default.
• W2317521207 countsByYear W23175212072020 @default.
• W2317521207 countsByYear W23175212072021 @default.
• W2317521207 countsByYear W23175212072022 @default.
• W2317521207 countsByYear W23175212072023 @default.
• W2317521207 crossrefType "journal-article" @default.
• W2317521207 hasAuthorship W2317521207A5019620793 @default.
• W2317521207 hasBestOaLocation W23175212071 @default.
• W2317521207 hasConcept C104317684 @default.
• W2317521207 hasConcept C126322002 @default.
• W2317521207 hasConcept C134018914 @default.
• W2317521207 hasConcept C150194340 @default.
• W2317521207 hasConcept C170493617 @default.
• W2317521207 hasConcept C185592680 @default.
• W2317521207 hasConcept C204232928 @default.
• W2317521207 hasConcept C24998067 @default.
• W2317521207 hasConcept C2777397205 @default.
• W2317521207 hasConcept C55493867 @default.
• W2317521207 hasConcept C71924100 @default.
• W2317521207 hasConceptScore W2317521207C104317684 @default.
• W2317521207 hasConceptScore W2317521207C126322002 @default.
• W2317521207 hasConceptScore W2317521207C134018914 @default.
• W2317521207 hasConceptScore W2317521207C150194340 @default.
• W2317521207 hasConceptScore W2317521207C170493617 @default.
• W2317521207 hasConceptScore W2317521207C185592680 @default.
• W2317521207 hasConceptScore W2317521207C204232928 @default.
• W2317521207 hasConceptScore W2317521207C24998067 @default.
• W2317521207 hasConceptScore W2317521207C2777397205 @default.
• W2317521207 hasConceptScore W2317521207C55493867 @default.
• W2317521207 hasConceptScore W2317521207C71924100 @default.
• W2317521207 hasIssue "5" @default.
• W2317521207 hasLocation W23175212071 @default.
• W2317521207 hasLocation W23175212072 @default.
• W2317521207 hasLocation W23175212073 @default.
• W2317521207 hasLocation W23175212074 @default.
• W2317521207 hasOpenAccess W2317521207 @default.
• W2317521207 hasPrimaryLocation W23175212071 @default.
• W2317521207 hasRelatedWork W1984619393 @default.
• W2317521207 hasRelatedWork W2034583712 @default.
• W2317521207 hasRelatedWork W2034768996 @default.
• W2317521207 hasRelatedWork W2054992011 @default.
• W2317521207 hasRelatedWork W2060618991 @default.

• next