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• W2317521607 abstract "Les complications biologiques et l’impact somatique des intoxications médicamenteuses volontaires (IMV) chez l’adolescent ont été peu évalués. L’objectif de notre étude, descriptive, prospective et monocentrique, était de décrire les circonstances du geste, les substances ingérées ainsi que leurs complications. Elle s’est déroulée au service d’accueil des urgences pédiatriques et dans les services de pédiatrie et réanimation pédiatrique du Centre hospitalier universitaire de Caen. Tous les enfants âgés de 10 à 18 ans s’étant présentés entre le 1er juin 2012 et le 1er juin 2013 pour une IMV ont été inclus. Une évaluation somatique et biologique a été réalisée à l’arrivée, et répétée pendant l’hospitalisation. Un questionnaire a été rempli en parallèle pour identifier les substances ingérées et les facteurs de risque de tentative de suicide (TS). Le paracétamol avait été la substance la plus utilisée comparativement aux autres médicaments (p = 0,01). Les douleurs abdominales à l’arrivée étaient significativement associées à la prise de paracétamol (p = 0,02). Au total, 3,4 % des adolescents ont présenté une insuffisance rénale aiguë, et 3,4 % une insuffisance hépatique aiguë en lien avec une prise de paracétamol à dose toxique. Les anomalies biologiques et l’examen somatique s’étaient normalisés avant la sortie d’hospitalisation. La durée moyenne d’hospitalisation a été de 7,1 jours. La prévention de l’accès aux traitements médicamenteux par les adolescents pourrait permettre une réduction du risque de survenue de complications biologiques. La prévention des récidives d’IMV reste également à améliorer pour permettre de diminuer la mortalité par répétition des TS. Biological complications in adolescents’ self-poisoning are not currently evaluated. The aim of this study was to describe the toxicological characteristics of suicide attempts, the ingested substances, and their complications to better prevent the risks associated with deliberate self-poisoning. This was a descriptive, prospective, single-center study. It took place in the pediatric emergency, hospitalization, and intensive care unit of the Caen University Hospital. All children aged 10–18 years who had presented to the pediatric emergency department between 1 June 2012 and 1 June 2013 for deliberate self-poisoning were included. Somatic evaluation was conducted for the protocol on arrival at the emergency room, and repeated during hospitalization, and biological evaluation was performed on arrival at the pediatric emergency unit and on the 5th day after the drug intoxication. A questionnaire was completed at this time to identify the substances ingested and the risk factors for suicide attempt. Acetaminophen was the most frequently chosen substance compared to other drugs in acute drug overdose (P = 0.01). Abdominal pain on arrival at the emergency room were significantly associated with acetaminophen (P = 0.02). In 10% of the cases, a transfer to the pediatric intensive care unit was required. In total, 3.4% had acute renal failure and 3.4% acute liver failure in connection with acetaminophen ingestion. Biological complications and symptoms disappeared prior to hospital discharge. The average hospital stay was 7.1 days. This study focused on biological complications in pediatric emergencies, but also later on deliberate self-poisoning to detect other complications. It seems important to detect the presence of liver or kidney failure, and more importantly whether there is acetaminophen ingestion. The prevention of suicide attempt recurrences also remains a priority, given the increased risk of mortality from repeating a suicide attempt. Systematization of biological assessments made in emergency situations but particularly in the hospital could improve the care of these adolescents." @default.
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• W2317521607 date "2016-05-01" @default.
• W2317521607 modified "2023-09-25" @default.
• W2317521607 title "Intoxications médicamenteuses volontaires chez 58 adolescents : étude prospective sur l’impact somatique et les complications biologiques" @default.
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• W2317521607 doi "https://doi.org/10.1016/j.arcped.2016.02.009" @default.
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