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• W2317571485 abstract "Objective: To assess the effect of combined chemotherapy on levels of Anti-Mullerian Hormone (AMH). Method: This is a prospective cohort study on 12 non-gynecologic cancer women aged 20 - 40 years who received combined chemotherapy treatment. AMH levels and menstrual pattern before and after three months of chemotherapy were examined. The relationships between age, chemotherapy regimens and the cumulative doses on the change of AMH were also analyzed. Result: The median age of subjects was 37 years (range 20 - 40 years). Pre chemotherapy AMH analysis revealed an inverse correlation between age and AMH levels (r = -0.715; p = 0.009). AMH levels after 3 months of combined chemotherapy drastically declined to 84.6% (p = 0.002). Multivariate analysis indicated that age and total cumulative dose were the main factors contributing to the AMH levels reduction (r = -0.679; p = 0.002 and r = 0.405; p = 0.027). Ten of 12 subjects (83.3%) experienced amenorrhea after 3 months of chemotherapy and had lower level of pre and postchemotherapy AMH compared to those who still maintained normal periods (p = 0.03 and 0.02). Conclusion: AMH levels in non-gynecological cancer women who received combined chemotherapy decreased dramatically after 3 months of chemotherapy. Main factors that contribute to this were the cumulative dose and age. Most of these subjects experienced amenorrhea after 3 months of chemotherapy. [Indones J Obstet Gynecol 2010; 34-3: 119-24] Keywords: ovarian reserve, chemotherapy, Anti Mullerian Hormone (AMH), ovarian function, gonadotoxic Tujuan: Mengetahui pengaruh kemoterapi kombinasi terhadap kadar Anti Mullerian Hormone (AMH). Metode: Penelitian ini merupakan studi kohort prospektif pada 12 pasien kanker non ginekologi berusia 20 - 40 tahun yang mendapatkan kemoterapi kombinasi. Kadar AMH dan pola haid sebelum dan setelah tiga bulan kemoterapi diperiksa. Hubungan antara faktor usia, rejimen kemoterapi dan dosis kumulatif terhadap perubahan kadar AMH juga dianalisis. Hasil: Median usia subjek adalah 37 tahun (rentang 20 - 40 tahun). Analisis AMH pra kemoterapi menunjukkan korelasi terbalik antara usia dengan kadar AMH (r = -0,715; p = 0,009). Kadar AMH setelah 3 bulan pemberian kemoterapi kombinasi menurun drastis hingga 84,6% (p = 0,002). Dari analisis multivariat didapatkan bahwa faktor usia dan dosis total kumulatif kemoterapilah yang berperan terhadap penurunan kadar AMH (r = -0,679; p = 0,002 dan r = 0,405; p = 0,027). Sebanyak 10 dari 12 subjek (83,3%) mengalami amenore setelah 3 bulan pemberian kemoterapi dan memiliki kadar AMH prakemoterapi maupun pascakemoterapi yang lebih rendah dibandingkan kelompok yang tetap memiliki haid yang normal (p = 0,03 dan 0,02). Kesimpulan: Kadar AMH penderita kanker non ginekologi yang mendapatkan kemoterapi kombinasi menurun drastis setelah 3 bulan pemberian kemoterapi dan faktor-faktor yang berperan terhadap penurunan tersebut adalah dosis kumulatif dan usia. Sebagian besar subjek mengalami amenore setelah 3 bulan pemberian kemoterapi. [Maj Obstet Ginekol Indones 2010; 34-3: 119-24] Kata kunci: cadangan ovarium, kemoterapi, Anti Mullerian Hormone (AMH), fungsi ovarium, gonadotoksik" @default.
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• W2317571485 date "2010-01-01" @default.
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• W2317571485 title "Gonadotoxic Effect of Combined Chemotherapy on Anti Müllerian Hormone (AMH) Level in non-Gynecologic Cancer Patients in Reproductive Age" @default.
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