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- W2317584910 abstract "Five selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) competitive inhibitors, hupehenols A–E (1–5), were isolated from Viburnum hupehense. The structure elucidation indicated that compounds 1–5 are new 20,21,22,23,24,25,26,27-octanordammarane triterpenoids. Their structures were established on the basis of NMR spectroscopic and mass spectrometric analysis. Hupehenols A–E (1–5) showed inhibition against human 11β-HSD1, with hupehenols B (2) and E (5) having IC50 values of 15.3 and 34.0 nM, respectively. Moreover, hupehenols C (3) and D (4) are highly selective inhibitors of human 11β-HSD1 when compared to murine 11β-HSD1." @default.
- W2317584910 created "2016-06-24" @default.
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- W2317584910 date "2015-01-15" @default.
- W2317584910 modified "2023-09-27" @default.
- W2317584910 title "Hupehenols A–E, Selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors from <i>Viburnum hupehense</i>" @default.
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- W2317584910 doi "https://doi.org/10.1021/np500896n" @default.
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