Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317607313> ?p ?o ?g. }
- W2317607313 abstract "During cortical development, NMDA receptors (NMDARs) facilitate presynaptic terminal formation, enhance neurotransmitter release, and are required in presynaptic neurons for spike timing-dependent LTD. However, the extent to which NMDARs are found within cortical presynaptic terminals has remained controversial, and the sub-synaptic localization and dynamics of axonal NMDARs are unknown. Here, using live confocal imaging and biochemical purification of presynaptic membranes, we provide strong evidence that NMDARs localize to presynaptic terminals in vitro and in vivo, in a developmentally regulated manner. NR1 and NR2B subunits are found within the active zone membrane, where they could respond to synaptic glutamate release. Surprisingly, NR1 also appears in glutamatergic and GABAergic synaptic vesicles. During synaptogenesis, NR1 is mobile throughout axons - including growth cones and filopodia, structures that are involved in synaptogenesis. Upon synaptogenic contact, NMDA receptors are quickly recruited to terminals by neuroligin-1/neurexin signaling. Unlike dendrites, the trafficking and distribution of axonal NR1 are insensitive to activity changes, including NMDA exposure, local glutamate uncaging or action potential blockade. These results support the idea that presynaptic NMDARs play an early role in presynaptic development." @default.
- W2317607313 created "2016-06-24" @default.
- W2317607313 creator A5008217752 @default.
- W2317607313 creator A5013644332 @default.
- W2317607313 creator A5019089944 @default.
- W2317607313 creator A5057013395 @default.
- W2317607313 creator A5064042759 @default.
- W2317607313 creator A5071782139 @default.
- W2317607313 creator A5072895309 @default.
- W2317607313 creator A5073562468 @default.
- W2317607313 creator A5076653839 @default.
- W2317607313 date "2014-01-01" @default.
- W2317607313 modified "2023-10-18" @default.
- W2317607313 title "Presynaptic NMDA receptors: dynamics and distribution in developing axons <i>in vitro</i> and <i>in vivo</i>" @default.
- W2317607313 cites W1580193914 @default.
- W2317607313 cites W1616958874 @default.
- W2317607313 cites W1812094318 @default.
- W2317607313 cites W1919311176 @default.
- W2317607313 cites W1952831770 @default.
- W2317607313 cites W1964444099 @default.
- W2317607313 cites W1965046166 @default.
- W2317607313 cites W1965974943 @default.
- W2317607313 cites W1966176569 @default.
- W2317607313 cites W1971781124 @default.
- W2317607313 cites W1974307776 @default.
- W2317607313 cites W1974583466 @default.
- W2317607313 cites W1974720828 @default.
- W2317607313 cites W1977228206 @default.
- W2317607313 cites W1978605718 @default.
- W2317607313 cites W1979131378 @default.
- W2317607313 cites W1980456323 @default.
- W2317607313 cites W1983092434 @default.
- W2317607313 cites W1983702397 @default.
- W2317607313 cites W1986710148 @default.
- W2317607313 cites W1988670106 @default.
- W2317607313 cites W1989203304 @default.
- W2317607313 cites W1992145070 @default.
- W2317607313 cites W1992669281 @default.
- W2317607313 cites W1994030229 @default.
- W2317607313 cites W1996445996 @default.
- W2317607313 cites W1998044218 @default.
- W2317607313 cites W1999023505 @default.
- W2317607313 cites W2001041036 @default.
- W2317607313 cites W2004747469 @default.
- W2317607313 cites W2007114792 @default.
- W2317607313 cites W2017910024 @default.
- W2317607313 cites W2021144046 @default.
- W2317607313 cites W2022963868 @default.
- W2317607313 cites W2024312922 @default.
- W2317607313 cites W2025653075 @default.
- W2317607313 cites W2025722885 @default.
- W2317607313 cites W2027265162 @default.
- W2317607313 cites W2030377743 @default.
- W2317607313 cites W2033759150 @default.
- W2317607313 cites W2040249614 @default.
- W2317607313 cites W2040619158 @default.
- W2317607313 cites W2045916207 @default.
- W2317607313 cites W2046165746 @default.
- W2317607313 cites W2046173010 @default.
- W2317607313 cites W2046485926 @default.
- W2317607313 cites W2048367346 @default.
- W2317607313 cites W2049322941 @default.
- W2317607313 cites W2050180703 @default.
- W2317607313 cites W2050692084 @default.
- W2317607313 cites W2053121988 @default.
- W2317607313 cites W2054838899 @default.
- W2317607313 cites W2058917641 @default.
- W2317607313 cites W2060647065 @default.
- W2317607313 cites W2060955491 @default.
- W2317607313 cites W2061326272 @default.
- W2317607313 cites W2061437035 @default.
- W2317607313 cites W2064352628 @default.
- W2317607313 cites W2067484466 @default.
- W2317607313 cites W2068016566 @default.
- W2317607313 cites W2069786648 @default.
- W2317607313 cites W2072282121 @default.
- W2317607313 cites W2072553414 @default.
- W2317607313 cites W2074035736 @default.
- W2317607313 cites W2076108722 @default.
- W2317607313 cites W2076636373 @default.
- W2317607313 cites W2083827575 @default.
- W2317607313 cites W2085393352 @default.
- W2317607313 cites W2086717125 @default.
- W2317607313 cites W2090874481 @default.
- W2317607313 cites W2091738825 @default.
- W2317607313 cites W2099387330 @default.
- W2317607313 cites W2101477554 @default.
- W2317607313 cites W2107214822 @default.
- W2317607313 cites W2113383916 @default.
- W2317607313 cites W2118084082 @default.
- W2317607313 cites W2119724264 @default.
- W2317607313 cites W2121737262 @default.
- W2317607313 cites W2123609069 @default.
- W2317607313 cites W2125390340 @default.
- W2317607313 cites W2127634492 @default.
- W2317607313 cites W2128469846 @default.
- W2317607313 cites W2130421403 @default.
- W2317607313 cites W2132915433 @default.
- W2317607313 cites W2134044586 @default.
- W2317607313 cites W2135884359 @default.