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- W2317612107 abstract "The nucleosome is now considered to be the basic organizational mode of eukaryotic chromatin, and intranuclear variations in nucleosome structure appear directly related to the controlled expression of the cell's genetic information (this volume). However, there is little information bearing upon such questions as whether there are specific interactions between the nucleosomal proteins and the DNA sequences with which they are associated. If such specific interactions occur, what is the nature of the proteins that confer specificity, and are such proteins responsible for the transcriptional activation or repression of a given DNA sequence? In addition, the question of whether the structure of the nucleosome has any direct influence on DNA sequence evolution has not as yet been approached. To resolve these questions, we have characterized the repressed heterochromatin portion of the nuclear chromatin and the associated repetitive DNA sequences by an enzymological dissection of the nuclei and of the purified..." @default.
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- W2317612107 date "1978-01-01" @default.
- W2317612107 modified "2023-09-25" @default.
- W2317612107 title "Mammalian Repetitive DNA and the Subunit Structure of Chromatin" @default.
- W2317612107 doi "https://doi.org/10.1101/sqb.1978.042.01.115" @default.
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