FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317617369> ?p ?o ?g. }

• W2317617369 endingPage "3925" @default.
• W2317617369 startingPage "3909" @default.
• W2317617369 abstract "The end of the life of a transport vesicle requires a complex series of tethering, docking, and fusion events. Tethering complexes play a crucial role in the recognition of membrane entities and bringing them into close opposition, thereby coordinating and controlling cellular trafficking events. Here we provide a comprehensive RNA interference analysis of the CORVET and HOPS tethering complexes in metazoans. Knockdown of CORVET components promoted RAB-7 recruitment to subapical membranes, whereas in HOPS knockdowns, RAB-5 was found also on membrane structures close to the cell center, indicating the RAB conversion might be impaired in the absence of these tethering complexes. Unlike in yeast, metazoans have two VPS33 homologues, which are Sec1/Munc18 (SM)-family proteins involved in the regulation of membrane fusion. We assume that in wild type, each tethering complex contains a specific SM protein but that they may be able to substitute for each other in case of absence of the other. Of importance, knockdown of both SM proteins allowed bypass of the endosome maturation block in sand-1 mutants. We propose a model in which the SM proteins in tethering complexes are required for coordinated flux of material through the endosomal system." @default.
• W2317617369 created "2016-06-24" @default.
• W2317617369 creator A5020638091 @default.
• W2317617369 creator A5038099252 @default.
• W2317617369 date "2014-12-01" @default.
• W2317617369 modified "2023-10-18" @default.
• W2317617369 title "Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in<i>Caenorhabditis elegans</i>" @default.
• W2317617369 cites W1519450813 @default.
• W2317617369 cites W1944127002 @default.
• W2317617369 cites W1968733649 @default.
• W2317617369 cites W1970589752 @default.
• W2317617369 cites W1973988284 @default.
• W2317617369 cites W1974485263 @default.
• W2317617369 cites W1976074435 @default.
• W2317617369 cites W1987628482 @default.
• W2317617369 cites W1991225856 @default.
• W2317617369 cites W1992116234 @default.
• W2317617369 cites W1992189978 @default.
• W2317617369 cites W1994500285 @default.
• W2317617369 cites W1999628208 @default.
• W2317617369 cites W2007647318 @default.
• W2317617369 cites W2011461336 @default.
• W2317617369 cites W2012764272 @default.
• W2317617369 cites W2023226895 @default.
• W2317617369 cites W2030427181 @default.
• W2317617369 cites W2032062018 @default.
• W2317617369 cites W2038492783 @default.
• W2317617369 cites W2046133662 @default.
• W2317617369 cites W2064268926 @default.
• W2317617369 cites W2070461863 @default.
• W2317617369 cites W2070740225 @default.
• W2317617369 cites W2078307081 @default.
• W2317617369 cites W2079368124 @default.
• W2317617369 cites W2079458003 @default.
• W2317617369 cites W2079687293 @default.
• W2317617369 cites W2089483770 @default.
• W2317617369 cites W2094205174 @default.
• W2317617369 cites W2094616509 @default.
• W2317617369 cites W2096657097 @default.
• W2317617369 cites W2097751194 @default.
• W2317617369 cites W2103913551 @default.
• W2317617369 cites W2104079020 @default.
• W2317617369 cites W2104969134 @default.
• W2317617369 cites W2110522042 @default.
• W2317617369 cites W2111499254 @default.
• W2317617369 cites W2117274420 @default.
• W2317617369 cites W2120348985 @default.
• W2317617369 cites W2123014011 @default.
• W2317617369 cites W2125293268 @default.
• W2317617369 cites W2125335261 @default.
• W2317617369 cites W2126003136 @default.
• W2317617369 cites W2129797485 @default.
• W2317617369 cites W2133215208 @default.
• W2317617369 cites W2136243038 @default.
• W2317617369 cites W2137685927 @default.
• W2317617369 cites W2138181980 @default.
• W2317617369 cites W2142846853 @default.
• W2317617369 cites W21436401 @default.
• W2317617369 cites W2144882708 @default.
• W2317617369 cites W2145914833 @default.
• W2317617369 cites W2146015738 @default.
• W2317617369 cites W2151581724 @default.
• W2317617369 cites W2151890795 @default.
• W2317617369 cites W2152224383 @default.
• W2317617369 cites W2155347323 @default.
• W2317617369 cites W2159803165 @default.
• W2317617369 cites W2161378572 @default.
• W2317617369 cites W2161476009 @default.
• W2317617369 cites W2161518588 @default.
• W2317617369 cites W2161709372 @default.
• W2317617369 cites W2166155213 @default.
• W2317617369 cites W2166732191 @default.
• W2317617369 cites W2168210128 @default.
• W2317617369 cites W2168698734 @default.
• W2317617369 cites W2170117855 @default.
• W2317617369 cites W2312836697 @default.
• W2317617369 cites W2394930385 @default.
• W2317617369 doi "https://doi.org/10.1091/mbc.e13-12-0710" @default.
• W2317617369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4244200" @default.
• W2317617369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25273556" @default.
• W2317617369 hasPublicationYear "2014" @default.
• W2317617369 type Work @default.
• W2317617369 sameAs 2317617369 @default.
• W2317617369 citedByCount "16" @default.
• W2317617369 countsByYear W23176173692015 @default.
• W2317617369 countsByYear W23176173692016 @default.
• W2317617369 countsByYear W23176173692017 @default.
• W2317617369 countsByYear W23176173692018 @default.
• W2317617369 countsByYear W23176173692019 @default.
• W2317617369 countsByYear W23176173692020 @default.
• W2317617369 countsByYear W23176173692021 @default.
• W2317617369 crossrefType "journal-article" @default.
• W2317617369 hasAuthorship W2317617369A5020638091 @default.
• W2317617369 hasAuthorship W2317617369A5038099252 @default.
• W2317617369 hasBestOaLocation W23176173691 @default.
• W2317617369 hasConcept C102747710 @default.
• W2317617369 hasConcept C103038307 @default.
• W2317617369 hasConcept C104317684 @default.

• next