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- W2317629031 abstract "In 38 uraemic dialysed patients (17 normotensive, 21 hypertensive) we measured (1) erythrocyte sodium concentration [Na] and ouabain-sensitive sodium efflux, and (2) arterial pressure, cardiac index and total peripheral resistance. Erythrocyte Na—K pump activity was lower in hypertensive than in normotensive patients (P < 0.02). Hypertensive patients had significantly higher peripheral resistance than normotensive patients (P < 0.05), while the cardiac index was similar in both groups. Inverse correlations were found between the rate constant for ouabain-sensitive sodium efflux in erythrocytes and both systolic and diastolic pressure (r = −0.43 and r = −0.45, respectively; P < 0.01) and total peripheral resistance (r = −0.76; P < 0.0001). Our data suggest that reduced sodium transport by the Na-K pump plays a role in the pathogenesis of arterial hypertension in patients with chronic uraemia." @default.
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- W2317629031 date "1988-12-01" @default.
- W2317629031 modified "2023-10-15" @default.
- W2317629031 title "Pathogenesis of arterial hypertension in chronic uraemia" @default.
- W2317629031 doi "https://doi.org/10.1097/00004872-198812040-00113" @default.
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