FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317661410> ?p ?o ?g. }

• W2317661410 endingPage "119" @default.
• W2317661410 startingPage "119" @default.
• W2317661410 abstract "To the Editor: We concur the findings published in Pediatric Critical Care Medicine of Dr. Levin and colleagues (1), who found a 30% to 40% incidence of bacterial coinfection/concomitant bacterial pneumonia (CBP) in 23 “low-risk” infants ventilated for respiratory syncytial virus (RSV). Since our original prospective study covering the 2002–2005 period (2), we have continued to employ the strategy advocated by Dr. Levin and colleagues (1) and supported by Dr. Yogev in his accompanying editorial (3)—that is, perform tracheobronchial sampling on admission, use empirical antibiotics, and conduct a review/rationalization 48–72 hrs later once bacteriology culture results are available. Of 352 children ventilated for RSV infection between 2002 and 2009 (total number = 384, less 32 as no admission broncho-alveolar lavage was performed; median age 2.8 months, interquartile range 1.3–11.5 months), bacterial coinfection was found in up to 36%, with 18% (n = 72) having CBP and 18% “possible” bacterial coinfection (n = 73). We found no difference in the bacterial coinfection/CBP incidence between low-risk RSV patients and those with comorbidity (37% vs. 36%; Fisher's exact test, p = .9). We would challenge the clinical relevance in differentiating the two groups. Our diagnosis of bacterial coinfection/CBP or possible CBP (low bacterial growth) is based on pure growth densities (>105 colony-forming units/mL) plus leukocytes in the broncho-alveolar lavage. It is therefore similar, but microbiologically stronger, than the definitions utilized by Dr. Levin and colleagues (1) and Randolph et al (4). It also fulfils the call of Dr. Yogev (3) for quantitation or semiquantitation to increase specificity and overcomes his concerns of “the inherent problem of bacterial contamination.” A pure growth of a single species of >105 colony-forming units/mL plus a leukocyte count >100 × 106/L in the broncho-alveolar lavage qualifies for CBP, and a lower bacterial growth density or leukocyte count represents possible bacterial coinfection (2). The potential bacterial pathogens (CBP + possible) were as follows: Haemophilus influenzae, 52; Staphylococcus aureus, 38; Moraxella catarrhalis, 31; Streptococcus pneumoniae, 22; Pseudomonas, 16; Escherichia coli, six; Klebsiella, five; Enterobacter, five; methicillin-resistant S.aureus, four; Stenotrophomonas, three; S. agalactiae, two; Bordetella pertussis, two; Streptococcus group C, one, and Pneumocystis jirovecii, one. Thirty-five children had two bacteria cultured, and eight had more than two species. Contrary to skeptical criticism, it is difficult to believe that a heavy pure growth of a potential bacterial pathogen deep in a “virgin” tracheobronchial tree has been pushed down by recent intubation. Like Dr. Levin and colleagues (1), we too found total white cell, neutrophil or lymphocyte counts, and C-reactive protein unhelpful in differentiating CBP from RSV-only infection (all Mann-Whitney-Wilcoxon tests p > .2). Once again compared with the RSV-only group, the CBP group had a longer duration of ventilation (median 6 days, interquartile range 3.5–9 days vs. 5 days, 3–7.5 days; Mann-Whitney-Wilcoxon test, p = .03). Mortality continued to be similar in both groups (CBP 4.8% vs. RSV-only 5.6%; Fisher's exact test, p = .8). Based on our data plus those of other authors (1, 2, 4–6), we continue to employ and advocate the strategy of tracheobronchial sampling on intubation or pediatric intensive care unit admission, empirical antibiotic cover (cefotaxime), and then review/rationalization with microbiological results in this vulnerable patient group. The authors have not disclosed any potential conflicts of interest. Kentigern Thorburn, MD, FCPaed Nayan Shetty, MD Andrew P. Darbyshire, MSc Paediatric Intensive Care Unit, Alder Hey Children's Hospital, Liverpool, United Kingdom" @default.
• W2317661410 created "2016-06-24" @default.
• W2317661410 creator A5018552192 @default.
• W2317661410 creator A5031288810 @default.
• W2317661410 creator A5041318345 @default.
• W2317661410 date "2011-01-01" @default.
• W2317661410 modified "2023-10-10" @default.
• W2317661410 title "Concomitant bacterial pneumonia and empirical antibiotics in severe respiratory syncytial virus infection" @default.
• W2317661410 cites W1975629287 @default.
• W2317661410 cites W1986034755 @default.
• W2317661410 cites W2068871212 @default.
• W2317661410 cites W2133966455 @default.
• W2317661410 cites W2145154571 @default.
• W2317661410 doi "https://doi.org/10.1097/pcc.0b013e3181fe292f" @default.
• W2317661410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21209581" @default.
• W2317661410 hasPublicationYear "2011" @default.
• W2317661410 type Work @default.
• W2317661410 sameAs 2317661410 @default.
• W2317661410 citedByCount "4" @default.
• W2317661410 countsByYear W23176614102012 @default.
• W2317661410 countsByYear W23176614102014 @default.
• W2317661410 crossrefType "journal-article" @default.
• W2317661410 hasAuthorship W2317661410A5018552192 @default.
• W2317661410 hasAuthorship W2317661410A5031288810 @default.
• W2317661410 hasAuthorship W2317661410A5041318345 @default.
• W2317661410 hasBestOaLocation W23176614101 @default.
• W2317661410 hasConcept C119060515 @default.
• W2317661410 hasConcept C120665830 @default.
• W2317661410 hasConcept C121332964 @default.
• W2317661410 hasConcept C126322002 @default.
• W2317661410 hasConcept C177713679 @default.
• W2317661410 hasConcept C203014093 @default.
• W2317661410 hasConcept C2522874641 @default.
• W2317661410 hasConcept C2776345407 @default.
• W2317661410 hasConcept C2777813720 @default.
• W2317661410 hasConcept C2777914695 @default.
• W2317661410 hasConcept C2779384505 @default.
• W2317661410 hasConcept C501593827 @default.
• W2317661410 hasConcept C534529494 @default.
• W2317661410 hasConcept C61511704 @default.
• W2317661410 hasConcept C71924100 @default.
• W2317661410 hasConcept C86803240 @default.
• W2317661410 hasConcept C89423630 @default.
• W2317661410 hasConceptScore W2317661410C119060515 @default.
• W2317661410 hasConceptScore W2317661410C120665830 @default.
• W2317661410 hasConceptScore W2317661410C121332964 @default.
• W2317661410 hasConceptScore W2317661410C126322002 @default.
• W2317661410 hasConceptScore W2317661410C177713679 @default.
• W2317661410 hasConceptScore W2317661410C203014093 @default.
• W2317661410 hasConceptScore W2317661410C2522874641 @default.
• W2317661410 hasConceptScore W2317661410C2776345407 @default.
• W2317661410 hasConceptScore W2317661410C2777813720 @default.
• W2317661410 hasConceptScore W2317661410C2777914695 @default.
• W2317661410 hasConceptScore W2317661410C2779384505 @default.
• W2317661410 hasConceptScore W2317661410C501593827 @default.
• W2317661410 hasConceptScore W2317661410C534529494 @default.
• W2317661410 hasConceptScore W2317661410C61511704 @default.
• W2317661410 hasConceptScore W2317661410C71924100 @default.
• W2317661410 hasConceptScore W2317661410C86803240 @default.
• W2317661410 hasConceptScore W2317661410C89423630 @default.
• W2317661410 hasIssue "1" @default.
• W2317661410 hasLocation W23176614101 @default.
• W2317661410 hasLocation W23176614102 @default.
• W2317661410 hasLocation W23176614103 @default.
• W2317661410 hasOpenAccess W2317661410 @default.
• W2317661410 hasPrimaryLocation W23176614101 @default.
• W2317661410 hasRelatedWork W1970488797 @default.
• W2317661410 hasRelatedWork W2113539731 @default.
• W2317661410 hasRelatedWork W2366658537 @default.
• W2317661410 hasRelatedWork W2377393846 @default.
• W2317661410 hasRelatedWork W2384525989 @default.
• W2317661410 hasRelatedWork W2384646478 @default.
• W2317661410 hasRelatedWork W2413955971 @default.
• W2317661410 hasRelatedWork W285406328 @default.
• W2317661410 hasRelatedWork W4300920804 @default.
• W2317661410 hasRelatedWork W4309834956 @default.
• W2317661410 hasVolume "12" @default.
• W2317661410 isParatext "false" @default.
• W2317661410 isRetracted "false" @default.
• W2317661410 magId "2317661410" @default.
• W2317661410 workType "article" @default.