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- W2317668891 abstract "The anticarcinogenic potential of phytoproteins isolated from B.diffusa and C. aculeatum were evaluated in MCF-7 cell lines obtained from human breast adenocarcinoma having the membrane receptor for estrogens and androgen. Cells were grown in Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum, 0.1% antibiotic-antimycotic in a humidified atmosphere in 5% CO 2 at 37°C. Monolayered batches of MCF7 cells showing cell viability more than 95% in Trypan Blue Dye exclusion test were used in all the experiments. Independent exposure of proteins of Boerhaavia diffusa showed a dose dependent reduction in cell growth at 0.1X, 1.0X and 10.0X concentrations in all the time intervals i.e., from 24 hr to 96 hr. However, 20.0X concentration were found to be cytotoxic. Isolated proteins of Clerodenrum aculeatum were found almost equally effective under experimental conditions. Interestingly, a synergistic effect on the growth inhibition (36.5 ± 3.1%) was observed on co-exposure of proteins of both the plants. However, mixture of proteins was also found to be cytotoxic at 20.0X concentration. The data of cell proliferation assay were also corresponding to the growth inhibition. Findings are suggestive that the combination of isolated proteins from Boerhaavia diffusa and Clerodendrum aculeatum have the potential of growth inhibition in MCF-7 cells under experimental conditions without having any cytotoxicity up to 10.0X concentrations and thus could be a useful anticancerous drug of future and will also be helpful for rural health care." @default.
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- W2317668891 date "2012-01-01" @default.
- W2317668891 modified "2023-10-02" @default.
- W2317668891 title "Modulatory Effect of Phytoproteins Isolated from Roots of Boerhaavia diffusa and Leaves of Clerodendrum aculeatum on Neoplastic Growth of Human Breast Cancer Cell Line" @default.
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- W2317668891 doi "https://doi.org/10.4172/scientificreports.429" @default.
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