FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317677501> ?p ?o ?g. }

• W2317677501 abstract "Event Abstract Back to Event Caffeine and adenosine a2a receptor antagonists prevent memmory impairment and synaptotoxicity in adults triggered by a conclusive episode in early life Giana P. Cognato1, 2, Paula M. Agostinho1*, Jorg Hockemeyer3, Christa E. Muller3, Diogo O. Souza2 and Rodrigo A. Cunha1 1 University of Coimbra, Center for Neurosciences of Coimbra, Institute of Biochemistry, Faculty of Medicine, Portugal 2 Universidade Federal do Rio Grande do Sul, Departamento de Bioquimica, Brazil 3 University of Bonn, Pharmazeutische Chemie I, Pharmazeutisches Institut, Germany Seizures early in life cause long term behavioural modifications, namely long term memory deficits in experimental animals. Since caffeine and adenosine A2A receptor (A2AR) antagonists prevent memory deficits in adults, we now investigated if they also prevented the long term memory deficits caused by a convulsive period early in life. Administration of kainate (KA, 2 mg/kg) to 7 days old (P7) rats caused a single period of self-extinguishable convulsions which lead to a poorer memory performance in the Y-maze when rats were 90 days old (P90), without modification of locomotion or anxiety-like behaviour in the elevated plus maze. The hippocampus of these adult rats treated with kainate at P7 displayed a lower density of synaptic proteins such as SNAP25 and syntaxin (but not synaptophysin), as well as vesicular glutamate transporters type 1 (but not vesicular GABA transporters), with no changes in PSD95, NMDA receptor subunits (NR1, NR2A, NR2B) or AMPA receptor subunits (GluR1, GluR2) compared to controls; also, there was no evidence of overt neuronal damage (cresyl violet staining of hippocampal sections) or astrogliosis (Western blot analysis and immunohistochemical staining of brain sections). Caffeine (1 g/L) or the A2AR antagonist, KW6002 (3 mg/kg) applied in the drinking water from P21 onwards, prevented these memory deficits in P90 rats treated with KA at P7, as well as the accompanying synaptotoxicity. These results show that a single convulsive episode in early childhood causes a delayed memory deficit in adulthood accompanied by a glutamatergic synaptotoxicity that was prevented by caffeine or adenosine A2AR antagonists.Supported by FCT and CAPESGRICES Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Poster Presentation Topic: Abstracts Citation: Cognato GP, Agostinho PM, Hockemeyer J, Muller CE, Souza DO and Cunha RA (2009). Caffeine and adenosine a2a receptor antagonists prevent memmory impairment and synaptotoxicity in adults triggered by a conclusive episode in early life. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.054 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 06 Aug 2009; Published Online: 06 Aug 2009. * Correspondence: Paula M Agostinho, University of Coimbra, Center for Neurosciences of Coimbra, Institute of Biochemistry, Faculty of Medicine, Alicante, Portugal, pagost@cnc.cj.uc.pt Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Giana P Cognato Paula M Agostinho Jorg Hockemeyer Christa E Muller Diogo O Souza Rodrigo A Cunha Google Giana P Cognato Paula M Agostinho Jorg Hockemeyer Christa E Muller Diogo O Souza Rodrigo A Cunha Google Scholar Giana P Cognato Paula M Agostinho Jorg Hockemeyer Christa E Muller Diogo O Souza Rodrigo A Cunha PubMed Giana P Cognato Paula M Agostinho Jorg Hockemeyer Christa E Muller Diogo O Souza Rodrigo A Cunha Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
• W2317677501 created "2016-06-24" @default.
• W2317677501 creator A5085233584 @default.
• W2317677501 date "2009-01-01" @default.
• W2317677501 modified "2023-10-16" @default.
• W2317677501 title "Caffeine and adenosine a2a receptor antagonists prevent memmory impairment and synaptotoxicity in adults triggered by a conclusive episode in early life" @default.
• W2317677501 doi "https://doi.org/10.3389/conf.neuro.01.2009.11.054" @default.
• W2317677501 hasPublicationYear "2009" @default.
• W2317677501 type Work @default.
• W2317677501 sameAs 2317677501 @default.
• W2317677501 citedByCount "0" @default.
• W2317677501 crossrefType "journal-article" @default.
• W2317677501 hasAuthorship W2317677501A5085233584 @default.
• W2317677501 hasBestOaLocation W23176775011 @default.
• W2317677501 hasConcept C126322002 @default.
• W2317677501 hasConcept C15744967 @default.
• W2317677501 hasConcept C160268369 @default.
• W2317677501 hasConcept C169760540 @default.
• W2317677501 hasConcept C170493617 @default.
• W2317677501 hasConcept C189184402 @default.
• W2317677501 hasConcept C2778500429 @default.
• W2317677501 hasConcept C2778938600 @default.
• W2317677501 hasConcept C2781161787 @default.
• W2317677501 hasConcept C61174792 @default.
• W2317677501 hasConcept C67018056 @default.
• W2317677501 hasConcept C67907053 @default.
• W2317677501 hasConcept C71924100 @default.
• W2317677501 hasConcept C98274493 @default.
• W2317677501 hasConceptScore W2317677501C126322002 @default.
• W2317677501 hasConceptScore W2317677501C15744967 @default.
• W2317677501 hasConceptScore W2317677501C160268369 @default.
• W2317677501 hasConceptScore W2317677501C169760540 @default.
• W2317677501 hasConceptScore W2317677501C170493617 @default.
• W2317677501 hasConceptScore W2317677501C189184402 @default.
• W2317677501 hasConceptScore W2317677501C2778500429 @default.
• W2317677501 hasConceptScore W2317677501C2778938600 @default.
• W2317677501 hasConceptScore W2317677501C2781161787 @default.
• W2317677501 hasConceptScore W2317677501C61174792 @default.
• W2317677501 hasConceptScore W2317677501C67018056 @default.
• W2317677501 hasConceptScore W2317677501C67907053 @default.
• W2317677501 hasConceptScore W2317677501C71924100 @default.
• W2317677501 hasConceptScore W2317677501C98274493 @default.
• W2317677501 hasLocation W23176775011 @default.
• W2317677501 hasOpenAccess W2317677501 @default.
• W2317677501 hasPrimaryLocation W23176775011 @default.
• W2317677501 hasRelatedWork W1754931819 @default.
• W2317677501 hasRelatedWork W1969277633 @default.
• W2317677501 hasRelatedWork W1972728329 @default.
• W2317677501 hasRelatedWork W2025676835 @default.
• W2317677501 hasRelatedWork W2032086168 @default.
• W2317677501 hasRelatedWork W2038917760 @default.
• W2317677501 hasRelatedWork W2104417933 @default.
• W2317677501 hasRelatedWork W2127692778 @default.
• W2317677501 hasRelatedWork W2401653406 @default.
• W2317677501 hasRelatedWork W2595054512 @default.
• W2317677501 hasVolume "3" @default.
• W2317677501 isParatext "false" @default.
• W2317677501 isRetracted "false" @default.
• W2317677501 magId "2317677501" @default.
• W2317677501 workType "article" @default.