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• W23176963 endingPage "233" @default.
• W23176963 startingPage "209" @default.
• W23176963 abstract "The level and turnover of phosphoinositides (PIs) are tightly controlled by a large set of PI-specific enzymes (PI kinases and phosphatases). Mammalian PI phosphatases are conserved through evolution and among this large family the dual-specificity phosphatase (PTP/DSP) are metal-independent enzymes displaying the amino acid signature Cys-X5-Arg-Thr/Ser (CX5RT/S) in their active site. Such catalytic site characterizes the myotubularin 3-phosphatases that dephosphorylate PtdIns3P and PtdIns(3,5)P 2 and produce PtdIns5P. Substrates of myotubularins have been implicated in endocytosis and membrane trafficking while PtdIns5P may have a role in signal transduction. As a paradox, 6 of the 14 members of the myotubularin family lack enzymatic activity and are considered as dead phosphatases. Several myotubularins have been genetically linked to human diseases: MTM1 is mutated in the congenital myopathy X-linked centronuclear or myotubular myopathy (XLCNM) and MTMR14 (JUMPY) has been linked to an autosomal form of such disease, while MTMR2 and MTMR13 are mutated in Charcot-Marie-Tooth (CMT) neuropathies. Furthermore, recent evidences from genetic association studies revealed that several other myotubularins could be associated to chronic disorders such as cancer and obesity, highlighting their importance for human health. Here, we discuss cellular and physiological roles of myotubularins and their implication in human diseases, and we present potential pathological mechanisms affecting specific tissues in myotubularin-associated diseases." @default.
• W23176963 created "2016-06-24" @default.
• W23176963 creator A5028726673 @default.
• W23176963 creator A5077318603 @default.
• W23176963 creator A5085289587 @default.
• W23176963 date "2012-01-01" @default.
• W23176963 modified "2023-10-03" @default.
• W23176963 title "Myotubularin Phosphoinositide Phosphatases in Human Diseases" @default.
• W23176963 cites W1513517412 @default.
• W23176963 cites W1614056212 @default.
• W23176963 cites W1632617569 @default.
• W23176963 cites W1735562555 @default.
• W23176963 cites W1911594896 @default.
• W23176963 cites W1913849939 @default.
• W23176963 cites W1964344010 @default.
• W23176963 cites W1964381789 @default.
• W23176963 cites W1965476757 @default.
• W23176963 cites W1966849450 @default.
• W23176963 cites W1967558857 @default.
• W23176963 cites W1967968612 @default.
• W23176963 cites W1972564132 @default.
• W23176963 cites W1973369613 @default.
• W23176963 cites W1973747284 @default.
• W23176963 cites W1975467499 @default.
• W23176963 cites W1975782237 @default.
• W23176963 cites W1975834289 @default.
• W23176963 cites W1983576132 @default.
• W23176963 cites W1984366092 @default.
• W23176963 cites W1985076246 @default.
• W23176963 cites W1987636668 @default.
• W23176963 cites W1994654693 @default.
• W23176963 cites W1995841153 @default.
• W23176963 cites W1997306286 @default.
• W23176963 cites W2002425106 @default.
• W23176963 cites W2003295985 @default.
• W23176963 cites W2004356154 @default.
• W23176963 cites W2007669066 @default.
• W23176963 cites W2007898433 @default.
• W23176963 cites W2011679829 @default.
• W23176963 cites W2012379047 @default.
• W23176963 cites W2016343839 @default.
• W23176963 cites W2017955219 @default.
• W23176963 cites W2019784504 @default.
• W23176963 cites W2022876043 @default.
• W23176963 cites W2025878297 @default.
• W23176963 cites W2036806208 @default.
• W23176963 cites W2037708995 @default.
• W23176963 cites W2037984910 @default.
• W23176963 cites W2039885998 @default.
• W23176963 cites W2040513834 @default.
• W23176963 cites W2042743700 @default.
• W23176963 cites W2043617798 @default.
• W23176963 cites W2045017287 @default.
• W23176963 cites W2046771580 @default.
• W23176963 cites W2049651968 @default.
• W23176963 cites W2050346490 @default.
• W23176963 cites W2053365501 @default.
• W23176963 cites W2053849194 @default.
• W23176963 cites W2055877882 @default.
• W23176963 cites W2056070148 @default.
• W23176963 cites W2057383532 @default.
• W23176963 cites W2057777556 @default.
• W23176963 cites W2058988966 @default.
• W23176963 cites W2061720685 @default.
• W23176963 cites W2063448502 @default.
• W23176963 cites W2064230225 @default.
• W23176963 cites W206660548 @default.
• W23176963 cites W2068427129 @default.
• W23176963 cites W2068752653 @default.
• W23176963 cites W2068781628 @default.
• W23176963 cites W2069680849 @default.
• W23176963 cites W2077091529 @default.
• W23176963 cites W2078984684 @default.
• W23176963 cites W2080244997 @default.
• W23176963 cites W2082379606 @default.
• W23176963 cites W2084440375 @default.
• W23176963 cites W2086921460 @default.
• W23176963 cites W2089518047 @default.
• W23176963 cites W2089648887 @default.
• W23176963 cites W2089858031 @default.
• W23176963 cites W2091358183 @default.
• W23176963 cites W2091884933 @default.
• W23176963 cites W2092215576 @default.
• W23176963 cites W2094294388 @default.
• W23176963 cites W2094409681 @default.
• W23176963 cites W2098123098 @default.
• W23176963 cites W2099081111 @default.
• W23176963 cites W2102901905 @default.
• W23176963 cites W2103545941 @default.
• W23176963 cites W2104842054 @default.
• W23176963 cites W2109859083 @default.
• W23176963 cites W2111043607 @default.
• W23176963 cites W2116524329 @default.
• W23176963 cites W2120077272 @default.
• W23176963 cites W2121796638 @default.
• W23176963 cites W2123948343 @default.
• W23176963 cites W2124140485 @default.
• W23176963 cites W2126114662 @default.

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